Varaico: Literature-Extracted Genetic Variants

Gene:LEPR
Variant:p.K109R
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LEPR

NM_002303.6:p.K109R

Associated Papers

Genetic variants underlying precancerous conditions of hepatocellular carcinoma.

Guerrero JJG et al.

International Journal of Cancer, 2026

Is Predisposition to T2D Impacted by Polymorphisms in Genes Involved in Insulin Signaling and Cellular Bioenergetics?

Pati B et al.

Acta Physiologica (oxford, England), 2025

Association of Obstructive Sleep Apnea Syndrome with Leptin Receptor Gene Q223R and K109R Single Nucleotide Polymorphisms in the Iranian Kurdish Population.

Alizadeh Severi A et al.

Genetic Testing and Molecular Biomarkers, 2025

Preliminary insight into the potential role of Leptin Receptor Polymorphisms in Type 2 Diabetes Risk: case-control study and bioinformatics analysis.

Sabeti Akbar-Abad M et al.

Journal of Diabetes and Metabolic Disorders, 2025

Association of LEPR Gene Polymorphisms With Youth-Onset Diabetes in Bangladesh.

Shayedat-Ullah M et al.

Cureus, 2025

LEP rs7799039 and LEPR rs1137101 gene variants are not associated with clinical features in patients with metabolic syndrome in the Turkish population.

Jabbarli M et al.

Laboratory Medicine, 2025

Leptin receptor polymorphism increases the risk of painful symptoms in Brazilian women with endometriosis.

Cardoso JV et al.

Revista Brasileira De Ginecologia E Obstetricia : Revista Da Federacao Brasileira Das Sociedades De Ginecologia E Obstetricia, 2025

The rs7799039 variant in the leptin gene promoter drives insulin resistance through reduced serum leptin levels.

Song Y et al.

Frontiers in Endocrinology, 2025

PNPLA3-Ile148Met and TM6SF2-Glu167Lys increase susceptibility to metabolic dysfunction-associated steatotic liver disease in children.

Yao H et al.

Frontiers in Endocrinology, 2025

Genetic Variants of Obesity in Malaysia: A Scoping Review.

Hamzah SS et al.

Genes, 2024

Leptin receptor Gln223Arg and Lys109Arg polymorphisms may be associated with HBV-related hepatocellular carcinoma risk: A system review and meta-analysis.

Dong X et al.

Environmental Toxicology, 2024

The influence of nutritional status, lipid profile, leptin concentration and polymorphism of genes encoding leptin and neuropeptide Y on the effectiveness of immunotherapy in advanced NSCLC patients.

Frąk M et al.

Bmc Cancer, 2024

Genetic Variations and Nonalcoholic Fatty Liver Disease: Field Synopsis, Systematic Meta-Analysis, and Epidemiological Evidence.

Li YM et al.

Biomedical and Environmental Sciences : Bes, 2024

39198240 (PubMed )
Supplement: cfb0899a-32e9-4dbf-91a2-828213d28f7c.pdf

A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers.

Hu WQ et al.

Biomedical and Environmental Sciences : Bes, 2024

Association of leptin receptor polymorphisms with susceptibility of non-small cell lung cancer: Evidence from 2249 subjects.

Tang W et al.

Cancer Medicine, 2024

Meta-analysis investigating the impact of the LEPR rs1137101 (A>G) polymorphism on obesity risk in Asian and Caucasian ethnicities.

Supti DA et al.

Heliyon, 2024

38496879 (PubMed )
Supplement: mmc1.docx

Novel NARS2 variants in a patient with early-onset status epilepticus: case study and literature review.

Yang N et al.

Bmc Pediatrics, 2024

38310242 (PubMed )
Supplement: 12887_2024_4553_MOESM1_ESM.xlsx › trio.hg38.filter

Association between LEPR Genotype and Gut Microbiome in Healthy Non-Obese Korean Adults.

Cha YJ et al.

Biomolecules & Therapeutics, 2024

In the context of the triple burden of malnutrition: A systematic review of gene-diet interactions and nutritional status.

Tan PY et al.

Critical Reviews in Food Science and Nutrition, 2024

Association of leptin receptor gene Gln223Arg polymorphism with insulin resistance and hyperglycemia in patients with metabolic syndrome.

Mirrakhimov E et al.

Archives of Medical Science : Ams, 2024

Effect of leptin concentrations and leptin receptor gene polymorphisms on the outcome of renal transplantation.

García-Pino G et al.

Archives of Medical Science : Ams, 2024

Genetic variant in the AGT gene (rs699-GG) is associated with severe COVID-19 in Brazilian patients.

Farias PCS et al.

Anais Da Academia Brasileira De Ciencias, 2024

Association between genetic polymorphisms of leptin receptor and preeclampsia in Chinese women.

Zeng S et al.

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2023

Correlation of Q223R and K109R polymorphisms in leptin receptor gene with susceptibility of breast cancer: A systematic review and meta-analysis.

Zhu S et al.

Journal of the Chinese Medical Association : Jcma, 2023

Integrating Common Risk Factors with Polygenic Scores Improves the Prediction of Type 2 Diabetes.

Timasheva Y et al.

International Journal of Molecular Sciences, 2023

36674502 (PubMed )
Supplement: ijms-24-00984-s001.zip › ijms-2028364-supplementary › Supplementary_tables_S1_S3_S4_S5.pdf

GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population.

Prodan A et al.

Endocrine Regulations, 2023

Decoding the genetic relationship between Alzheimer's disease and type 2 diabetes: potential risk variants and future direction for North Africa.

Boukhalfa W et al.

Frontiers in Aging Neuroscience, 2023

37342358 (PubMed )
Supplement: Table_2.XLSX › Table_2_SNPnexus_annotation

Genetic Factors in Familial Manifestation of Primary Mediastinal Large B-Cell Lymphoma over Two Generations.

Juskevicius D et al.

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology, 2023

Leptin Receptor Gln223Arg Polymorphism of Human Spermatozoa Associated with Male Infertility in a Chinese Population.

Mo Y et al.

International Journal of Clinical Practice, 2023

Genetic predisposition of LEPR (rs1137101) gene polymorphism related to type 2 diabetes mellitus - a meta-analysis.

Veerabathiran R et al.

Annals of Medicine, 2023

Large-Scale Targeted Sequencing Study of Ischemic Stroke in the Han Chinese Population.

Shi M et al.

Journal of the American Heart Association, 2022

Genetics of Obesity in Humans: A Clinical Review.

Mahmoud R et al.

International Journal of Molecular Sciences, 2022

Cytokine pathway variants modulate platelet production: IFNA16 is a thrombocytosis susceptibility locus in humans.

Gnatenko DV et al.

Blood Advances, 2022

35381074 (PubMed )
Supplement: advancesADV2021005648-suppl1.pdf

Leptin Signaling in Obesity and Colorectal Cancer.

Socol CT et al.

International Journal of Molecular Sciences, 2022

Genomic analysis to screen potential genes and mutations in children with non-syndromic early onset severe obesity: a multicentre study in Turkey.

Akinci A et al.

Molecular Biology Reports, 2022

Peptide ancestry informative markers in uterine neoplasms from women of European, African, and Asian ancestry.

Bateman NW et al.

Iscience, 2022

35036865 (PubMed )
Supplement: mmc2.xlsx › SupplementalTable1A

Variants of candidate genes associated with the risk of obstructive sleep apnea.

Yi M et al.

European Journal of Clinical Investigation, 2022

Single-Nucleotide Polymorphisms in LEP and LEPR Associated With Breast Cancer Risk: Results From a Multicenter Case-Control Study in Chinese Females.

Li L et al.

Frontiers in Oncology, 2022

Association between Genetic Polymorphisms and Risk of Kidney Posttransplant Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Xu S et al.

International Journal of Clinical Practice, 2022

35685576 (PubMed )
Supplement: 7140024.f1.zip › 7140024.f1 › Supplementary_Table_1__1_.pdf

Case report: Two unique nonsense mutations in HTRA1-related cerebral small vessel disease in a Chinese population and literature review.

Chen W et al.

Frontiers in Neurology, 2022

36619910 (PubMed )
Supplement: Data_Sheet_3.ZIP › case-C › 3.________ › CA2245B________.__________________________________.xlsx › sheet1

Prioritising positively selected variants in whole-genome sequencing data using FineMAV.

Wahyudi F et al.

Bmc Bioinformatics, 2021

34922440 (PubMed )
Supplement: 12859_2021_4506_MOESM2_ESM.xlsx › 90HC

Genetic polymorphisms associated with obesity in the Arab world: a systematic review.

Younes S et al.

International Journal of Obesity (2005), 2021

Association of PON1, LEP and LEPR Polymorphisms with Susceptibility to Breast Cancer: A Meta-Analysis.

Sayad S et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2021

Mitochondrial Mutations and Genetic Factors Determining NAFLD Risk.

Dabravolski SA et al.

International Journal of Molecular Sciences, 2021

LEP (-2548G>A LEP) and LEPR (223Gln>Arg, 109Lys>Arg) polymorphisms as breast cancer risk factors in the Polish female population.

Hołysz H et al.

Molecular Biology Reports, 2021

Genomic Signature of Oral Squamous Cell Carcinomas from Non-Smoking Non-Drinking Patients.

Koo K et al.

Cancers, 2021

33804510 (PubMed )
Supplement: cancers-13-01029-s001.zip › Supplementary_Data.xlsx › Somatic_mutations
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