Varaico: Literature-Extracted Genetic Variants

Gene:LEPR
Variant:p.Q223R
Back to variants list

LEPR

NM_002303.6:p.Q223R

Associated Papers

Investigation of leptin and leptin receptor gene polymorphisms in schizophrenia: further support for an association with attempted suicide.

Aytac HM et al.

Acta Neuropsychiatrica, 2026

Genetic variants underlying precancerous conditions of hepatocellular carcinoma.

Guerrero JJG et al.

International Journal of Cancer, 2026

Genetic Variant in Leptin rs7799039 Is Associated with Total Body Mineral Estimates, but Not with Fat Mass, in Young Healthy Adults.

Falbová D et al.

Nutrients, 2026

Leptin receptor rs1137101 polymorphism and altered leptin-sOb-R axis contribute to type 2 diabetes risk in Gujarat population.

Parmar N et al.

Frontiers in Endocrinology, 2026

Polygenic and single-locus selection on BMI during Polynesian expansion.

Miwa H et al.

Journal of Human Genetics, 2025

Evaluation of leptin and leptin receptor gene polymorphisms in bipolar disorder: focus on depressive episodes with atypical features.

Aytac HM et al.

Archives of Physiology and Biochemistry, 2025

Is Predisposition to T2D Impacted by Polymorphisms in Genes Involved in Insulin Signaling and Cellular Bioenergetics?

Pati B et al.

Acta Physiologica (oxford, England), 2025

Association of BDNF Val66Met genotype with obesity indicators and metabolic parameters.

İnan CM et al.

International Journal of Food Sciences and Nutrition, 2025

Impact of Bariatric Surgery on the Expression of Fertility-Related Genes in Obese Women: A Systematic Review of LEP, LEPR, MC4R, FTO, and POMC.

Voros C et al.

International Journal of Molecular Sciences, 2025

Association of Obstructive Sleep Apnea Syndrome with Leptin Receptor Gene Q223R and K109R Single Nucleotide Polymorphisms in the Iranian Kurdish Population.

Alizadeh Severi A et al.

Genetic Testing and Molecular Biomarkers, 2025

Genotype frequency analysis of rs2025804 LEPR genetic variant in Iranian population.

Najafi G et al.

Journal of Diabetes and Metabolic Disorders, 2025

Preliminary insight into the potential role of Leptin Receptor Polymorphisms in Type 2 Diabetes Risk: case-control study and bioinformatics analysis.

Sabeti Akbar-Abad M et al.

Journal of Diabetes and Metabolic Disorders, 2025

Evaluation of Adipokine Status and Leptin Receptor Gene Polymorphism in Patients with Severe Asthma.

Maimysheva S et al.

Diagnostics (basel, Switzerland), 2025

A case-control study on SH2B1 gene variants in obesity and obstructive sleep apnea severity: genetic risk factors in the leptin signaling pathway.

Kuccukturk S et al.

Expert Review of Endocrinology & Metabolism, 2025

Association of LEPR Gene Polymorphisms With Youth-Onset Diabetes in Bangladesh.

Shayedat-Ullah M et al.

Cureus, 2025

LEPR gene polymorphisms and pneumonia risk in Taiwanese schizophrenia patients under clozapine treatment.

Huang HC et al.

Schizophrenia Research, 2025

Genetic determinants of age at menarche: does the LIN28B gene play a role? A narrative review.

Tsinopoulou VR et al.

Hormones (athens, Greece), 2025

LEP rs7799039 and LEPR rs1137101 gene variants are not associated with clinical features in patients with metabolic syndrome in the Turkish population.

Jabbarli M et al.

Laboratory Medicine, 2025

The rs7799039 variant in the leptin gene promoter drives insulin resistance through reduced serum leptin levels.

Song Y et al.

Frontiers in Endocrinology, 2025

Investigating Leptin Gene Variants and Methylation Status in Relation to Breastfeeding and Preventing Obesity.

Kilic A et al.

Children (basel, Switzerland), 2024

Genetic Variants of Obesity in Malaysia: A Scoping Review.

Hamzah SS et al.

Genes, 2024

Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production.

Mathew AM et al.

The Journal of Infectious Diseases, 2024

Leptin receptor Gln223Arg and Lys109Arg polymorphisms may be associated with HBV-related hepatocellular carcinoma risk: A system review and meta-analysis.

Dong X et al.

Environmental Toxicology, 2024

The Arg/Arg genotype of leptin receptor gene Gln223Arg polymorphism may be an independent risk factor for nonalcoholic fatty liver disease.

Navari M et al.

Laboratory Medicine, 2024

The influence of nutritional status, lipid profile, leptin concentration and polymorphism of genes encoding leptin and neuropeptide Y on the effectiveness of immunotherapy in advanced NSCLC patients.

Frąk M et al.

Bmc Cancer, 2024

Sequencing methods, functional characterization, prevalence, and penetrance of rare coding mutations in panels of monogenic obesity genes from the leptin-melanocortin pathway: A systematic review.

Dosda S et al.

Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, 2024

38779716 (PubMed )
Supplement: supplement_1.pdf

A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers.

Hu WQ et al.

Biomedical and Environmental Sciences : Bes, 2024

Association of leptin receptor polymorphisms with susceptibility of non-small cell lung cancer: Evidence from 2249 subjects.

Tang W et al.

Cancer Medicine, 2024

Meta-analysis investigating the impact of the LEPR rs1137101 (A>G) polymorphism on obesity risk in Asian and Caucasian ethnicities.

Supti DA et al.

Heliyon, 2024

Unexpected identification of obesity-associated mutations in LEP and MC4R genes in patients with anorexia nervosa.

Rajcsanyi LS et al.

Scientific Reports, 2024

38528040 (PubMed )
Supplement: 41598_2024_57517_MOESM1_ESM.pdf

Gestational Weight Gain: Is the Role of Genetic Variants a Determinant? A Review.

Sámano R et al.

International Journal of Molecular Sciences, 2024

Genetic risk score for gestational weight gain.

Mikołajczyk-Stecyna J et al.

European Journal of Obstetrics, Gynecology, and Reproductive Biology, 2024

The Impact of Glucomannan, Inulin, and Psyllium Supplementation (SolowaysTM) on Weight Loss in Adults with FTO, LEP, LEPR, and MC4R Polymorphisms: A Randomized, Double-Blind, Placebo-Controlled Trial.

Pokushalov E et al.

Nutrients, 2024

Novel NARS2 variants in a patient with early-onset status epilepticus: case study and literature review.

Yang N et al.

Bmc Pediatrics, 2024

38310242 (PubMed )
Supplement: 12887_2024_4553_MOESM1_ESM.xlsx › trio.hg38.filter

Leptin and Leptin Receptor Polymorphisms in Infants and Their Parents: Correlation with Preterm Birth.

Savino F et al.

Genes, 2024

Association between LEPR Genotype and Gut Microbiome in Healthy Non-Obese Korean Adults.

Cha YJ et al.

Biomolecules & Therapeutics, 2024

In the context of the triple burden of malnutrition: A systematic review of gene-diet interactions and nutritional status.

Tan PY et al.

Critical Reviews in Food Science and Nutrition, 2024

Association of leptin receptor gene Gln223Arg polymorphism with insulin resistance and hyperglycemia in patients with metabolic syndrome.

Mirrakhimov E et al.

Archives of Medical Science : Ams, 2024

Effect of leptin concentrations and leptin receptor gene polymorphisms on the outcome of renal transplantation.

García-Pino G et al.

Archives of Medical Science : Ams, 2024

Genetic variant in the AGT gene (rs699-GG) is associated with severe COVID-19 in Brazilian patients.

Farias PCS et al.

Anais Da Academia Brasileira De Ciencias, 2024

Association between genetic polymorphisms of leptin receptor and preeclampsia in Chinese women.

Zeng S et al.

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2023

Association between leptin receptor polymorphisms and polycystic ovary syndrome risk: a meta-analysis based on 11 studies.

Wang NN et al.

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 2023

LEP (G2548A-G19A) and ADIPOQ (T45G-G276T) gene polymorphisms are associated with markers for metabolic syndrome.

Ortega FL et al.

Diabetology & Metabolic Syndrome, 2023

Leptin receptor gene polymorphisms in kidney transplant patients with post-transplant diabetes mellitus treated with tacrolimus.

Dziedziejko V et al.

International Immunopharmacology, 2023

Association of the Human Leptin Receptor Gene (rs1137101; Gln223Arg) Polymorphism and Circulating Leptin in Patients with Metabolic Syndrome in the Indian Population.

Parchwani D et al.

Indian Journal of Clinical Biochemistry : Ijcb, 2023

Circulating leptin level in osteoarthritis and associations between leptin receptor polymorphisms and disease susceptibility: A meta-analysis.

Lee YH et al.

International Journal of Rheumatic Diseases, 2023

Correlation of Q223R and K109R polymorphisms in leptin receptor gene with susceptibility of breast cancer: A systematic review and meta-analysis.

Zhu S et al.

Journal of the Chinese Medical Association : Jcma, 2023

Pharmacogenomics of response to statin treatment and susceptibility to statin-induced adverse drug reactions in Asians: a scoping review.

Yow HY et al.

Asian Biomedicine : Research, Reviews and News, 2023

1–50 of 577 papers
Select a paper to view details
UCSC Genome Browser·Imprint·Privacy·Terms·Feedback·Email Updates·

Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."