Varaico: Literature-Extracted Genetic Variants

Gene:LEPR
Variant:p.K656N
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LEPR

NM_002303.6:p.K656N

Associated Papers

Investigation of leptin and leptin receptor gene polymorphisms in schizophrenia: further support for an association with attempted suicide.

Aytac HM et al.

Acta Neuropsychiatrica, 2026

Leptin receptor rs1137101 polymorphism and altered leptin-sOb-R axis contribute to type 2 diabetes risk in Gujarat population.

Parmar N et al.

Frontiers in Endocrinology, 2026

Impact of Bariatric Surgery on the Expression of Fertility-Related Genes in Obese Women: A Systematic Review of LEP, LEPR, MC4R, FTO, and POMC.

Voros C et al.

International Journal of Molecular Sciences, 2025

Detection of Circulating mRNA Variants in Hepatocellular Carcinoma Patients Using Targeted RNAseq.

Zezulinski D et al.

Liver Cancer, 2025

40331063 (PubMed )
Supplement: Supplementary_material-Suppl.2-s2.xlsx › Supp_Table_7

Pathogenic variation in insulin resistance genes is common in polycystic ovary syndrome (PCOS): a strategy for causal gene discovery using whole-exome sequencing (WES) in complex traits.

Bauer R et al.

Medrxiv : the Preprint Server for Health Sciences, 2025

40832409 (PubMed )
Supplement: media-1.xlsx › S4_-_Variants_Identified

Association of Obstructive Sleep Apnea Syndrome with Leptin Receptor Gene Q223R and K109R Single Nucleotide Polymorphisms in the Iranian Kurdish Population.

Alizadeh Severi A et al.

Genetic Testing and Molecular Biomarkers, 2025

Association of LEPR Gene Polymorphisms With Youth-Onset Diabetes in Bangladesh.

Shayedat-Ullah M et al.

Cureus, 2025

Pathogenic variants in the fibronectin type III domain of leptin receptor: Molecular dynamics simulation and structural analysis.

Kato T et al.

Journal of Molecular Graphics & Modelling, 2025

The rs7799039 variant in the leptin gene promoter drives insulin resistance through reduced serum leptin levels.

Song Y et al.

Frontiers in Endocrinology, 2025

PNPLA3-Ile148Met and TM6SF2-Glu167Lys increase susceptibility to metabolic dysfunction-associated steatotic liver disease in children.

Yao H et al.

Frontiers in Endocrinology, 2025

Recurrent somatic mutations of FAT family cadherins induce an aggressive phenotype and poor prognosis in anaplastic large cell lymphoma.

Villa M et al.

British Journal of Cancer, 2024

39478125 (PubMed )
Supplement: 41416_2024_2881_MOESM1_ESM.pdf

Genetic Variants of Obesity in Malaysia: A Scoping Review.

Hamzah SS et al.

Genes, 2024

Leptin receptor Gln223Arg and Lys109Arg polymorphisms may be associated with HBV-related hepatocellular carcinoma risk: A system review and meta-analysis.

Dong X et al.

Environmental Toxicology, 2024

A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers.

Hu WQ et al.

Biomedical and Environmental Sciences : Bes, 2024

Whole exome sequencing and machine learning germline analysis of individuals presenting with extreme phenotypes of high and low risk of developing tobacco-associated lung adenocarcinoma.

Patiño-García A et al.

Ebiomedicine, 2024

38484556 (PubMed )
Supplement: mmc1.xlsx › Supp_Table_2

Meta-analysis investigating the impact of the LEPR rs1137101 (A>G) polymorphism on obesity risk in Asian and Caucasian ethnicities.

Supti DA et al.

Heliyon, 2024

38496879 (PubMed )
Supplement: mmc1.docx

Gene variants and the response to childhood obesity interventions: A systematic review and meta-analysis.

Chen J et al.

Clinical Nutrition (edinburgh, Scotland), 2024

Association of leptin receptor gene Gln223Arg polymorphism with insulin resistance and hyperglycemia in patients with metabolic syndrome.

Mirrakhimov E et al.

Archives of Medical Science : Ams, 2024

Effect of leptin concentrations and leptin receptor gene polymorphisms on the outcome of renal transplantation.

García-Pino G et al.

Archives of Medical Science : Ams, 2024

The Genetic Basis of Childhood Obesity: A Systematic Review.

Vourdoumpa A et al.

Nutrients, 2023

GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population.

Prodan A et al.

Endocrine Regulations, 2023

Leptin Receptor Gln223Arg Polymorphism of Human Spermatozoa Associated with Male Infertility in a Chinese Population.

Mo Y et al.

International Journal of Clinical Practice, 2023

Association between LEPR polymorphism and susceptibility of osteoporosis in Chinese Mulao people.

Ye G et al.

Artificial Cells, Nanomedicine, and Biotechnology, 2022

Genetics of ANCA-associated vasculitis: role in pathogenesis, classification and management.

Trivioli G et al.

Nature Reviews. Rheumatology, 2022

Leptin Signaling in Obesity and Colorectal Cancer.

Socol CT et al.

International Journal of Molecular Sciences, 2022

Genomic analysis to screen potential genes and mutations in children with non-syndromic early onset severe obesity: a multicentre study in Turkey.

Akinci A et al.

Molecular Biology Reports, 2022

Correspondence on Leptin Receptor Q223R Gene Polymorphism and Breast Cancer.

Kebayoon A et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2022

Association between Genetic Polymorphisms and Risk of Kidney Posttransplant Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Xu S et al.

International Journal of Clinical Practice, 2022

35685576 (PubMed )
Supplement: 7140024.f1.zip › 7140024.f1 › Supplementary_Table_1__1_.pdf

Case report: Two unique nonsense mutations in HTRA1-related cerebral small vessel disease in a Chinese population and literature review.

Chen W et al.

Frontiers in Neurology, 2022

36619910 (PubMed )
Supplement: Data_Sheet_6.ZIP › case2-C › 3.________ › CA2275B________.____Exonic_Variants.xlsx › sheet1

Advances in the genomics of ANCA-associated vasculitis-a view from East Asia.

Kawasaki A et al.

Genes and Immunity, 2021

Genomic Signature of Oral Squamous Cell Carcinomas from Non-Smoking Non-Drinking Patients.

Koo K et al.

Cancers, 2021

33804510 (PubMed )
Supplement: cancers-13-01029-s001.zip › Supplementary_Data.xlsx › Somatic_mutations

Leptin Gene and Leptin Receptor Gene Polymorphisms in Alcohol Use Disorder: Findings Related to Psychopathology.

Browning BD et al.

Frontiers in Psychiatry, 2021

Obesity in Children with Leptin Receptor Gene Polymorphisms.

Abaturov A et al.

Acta Medica (hradec Kralove), 2021

The Inter-Relation between Leptin Receptor (Q223R) Gene Polymorphism and the Risk of Egyptian Patients with HCC.

Karam HA et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2020

Combined donor-recipient genotypes of leptin receptor and adiponectin gene polymorphisms affect the incidence of complications after renal transplantation.

Mota-Zamorano S et al.

Molecular Genetics and Metabolism Reports, 2020

Association of Candidate Gene Polymorphism with Metabolic Syndrome among Mongolian Subjects: A Case-Control Study.

Chuluun-Erdene A et al.

Medical Sciences (basel, Switzerland), 2020

Leptin Levels and Q223R Leptin Receptor Gene Polymorphism in Obese Mexican Young Adults.

Diéguez-Campa CE et al.

Ejifcc, 2020

Leptin receptor gene polymorphisms c.668A>G and c.1968G>C in Sudanese women with preeclampsia: a case-control study.

Saad A et al.

Bmc Medical Genetics, 2020

Assessment of Genetic Aspects of Non-alcoholic Fatty Liver and Premature Cardiovascular Events.

Saki S et al.

Middle East Journal of Digestive Diseases, 2020

Computational and artificial neural network based study of functional SNPs of human LEPR protein associated with reproductive function.

Gandhi Muruganandhan S et al.

Journal of Cellular Biochemistry, 2019

Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth.

Helgeland Ø et al.

Nature Communications, 2019

Targeted Sequencing Analysis of the Leptin Receptor Gene Identifies Variants Associated with Obstructive Sleep Apnoea in Chinese Han Population.

Li J et al.

Lung, 2019

Whole exome sequencing reveals novel LEPR frameshift mutation in severely obese children from Western India.

Bhatt A et al.

Molecular Genetics & Genomic Medicine, 2019

Influence of K656N Polymorphism of the Leptin Receptor Gene on Obesity-Related Traits in Nondiabetic Afro-Caribbean Individuals.

Foucan L et al.

Metabolic Syndrome and Related Disorders, 2019

Variability in the leptin receptor gene and other risk factors for post-transplant diabetes mellitus in renal transplant recipients.

Mota-Zamorano S et al.

Annals of Medicine, 2019

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."