Varaico: Literature-Extracted Genetic Variants

Gene:LGALS3
Variant:p.R186S
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LGALS3

NM_002306.4:p.R186S

Associated Papers

SMURF1 mediates damaged lysosomal homeostasis by ubiquitinating PPP3CB to promote the activation of TFEB.

Xia Q et al.

Autophagy, 2025

Calcium signaling from damaged lysosomes induces cytoprotective stress granules.

Duran J et al.

The Embo Journal, 2024

A mechanism that transduces lysosomal damage signals to stress granule formation for cell survival.

Duran J et al.

Biorxiv : the Preprint Server for Biology, 2024

Mutation of the galectin-3 glycan-binding domain (Lgals3-R200S) enhances cortical bone expansion in male mice and trabecular bone mass in female mice.

Maupin KA et al.

Febs Open Bio, 2022

Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy.

Eapen VV et al.

Elife, 2021

Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.

Boza-Serrano A et al.

Acta Neuropathologica, 2019

A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface.

Stewart SE et al.

Journal of Cell Science, 2017

Spindle pole cohesion requires glycosylation-mediated localization of NuMA.

Magescas J et al.

Scientific Reports, 2017

Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells.

Grosset AA et al.

Bmc Cancer, 2014

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."