Associated Papers
A patient-derived mutation of epilepsy-linked LGI1 increases seizure susceptibility through regulating Kv1.1.
Zhou L et al.
Cell & Bioscience, 2023
The LGI1 protein: molecular structure, physiological functions and disruption-related seizures.
Baudin P et al.
Cellular and Molecular Life Sciences : Cmls, 2021
Insights into the mechanisms of epilepsy from structural biology of LGI1-ADAM22.
Yamagata A et al.
Cellular and Molecular Life Sciences : Cmls, 2020
Structural insights into leucine-rich repeat-containing synaptic cleft molecules.
Yamagata A et al.
Current Opinion in Structural Biology, 2019
Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.
Yamagata A et al.
Nature Communications, 2018
Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretation.
Traynelis J et al.
Genome Research, 2017
28864458 (PubMed )
Supplement: supp_gr.226589.117_Supplemental_Data_S1.xlsx › Data_S1
Genetic models of focal epilepsies.
Boillot M et al.
Journal of Neuroscience Methods, 2016
Screening LGI1 in a cohort of 26 lateral temporal lobe epilepsy patients with auditory aura from Turkey detects a novel de novo mutation.
Kesim YF et al.
Epilepsy Research, 2016
Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.
Yokoi N et al.
Nature Medicine, 2015
Low penetrance and effect on protein secretion of LGI1 mutations causing autosomal dominant lateral temporal epilepsy.
Di Bonaventura C et al.
Epilepsia, 2011
A computational model of the LGI1 protein suggests a common binding site for ADAM proteins.
Leonardi E et al.
Plos One, 2011
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