Associated Papers
Biallelic LGI1 and ADAM23 variants cause hippocampal epileptic encephalopathy via the LGI1-ADAM22/23 pathway.
Hirano Y et al.
Brain : a Journal of Neurology, 2025
Engineering of a high-fidelity Cas12a nuclease variant capable of allele-specific editing.
Wei J et al.
Plos Biology, 2024
38865309 (PubMed )
Supplement: pbio.3002680.s016.xlsx › ClinVar
The LGI1 protein: molecular structure, physiological functions and disruption-related seizures.
Baudin P et al.
Cellular and Molecular Life Sciences : Cmls, 2021
Insights into the mechanisms of epilepsy from structural biology of LGI1-ADAM22.
Yamagata A et al.
Cellular and Molecular Life Sciences : Cmls, 2020
Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.
Yamagata A et al.
Nature Communications, 2018
29670100 (PubMed )
Supplement: 41467_2018_3947_MOESM1_ESM.pdf
Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretation.
Traynelis J et al.
Genome Research, 2017
28864458 (PubMed )
Supplement: supp_gr.226589.117_Supplemental_Data_S1.xlsx › Data_S1
Genetic models of focal epilepsies.
Boillot M et al.
Journal of Neuroscience Methods, 2016
Screening LGI1 in a cohort of 26 lateral temporal lobe epilepsy patients with auditory aura from Turkey detects a novel de novo mutation.
Kesim YF et al.
Epilepsy Research, 2016
Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.
Yokoi N et al.
Nature Medicine, 2015
A computational model of the LGI1 protein suggests a common binding site for ADAM proteins.
Leonardi E et al.
Plos One, 2011
A novel three base-pair LGI1 deletion leading to loss of function in a family with autosomal dominant lateral temporal epilepsy and migraine-like episodes.
de Bellescize J et al.
Epilepsy Research, 2009
LGI1 mutations in autosomal dominant and sporadic lateral temporal epilepsy.
Nobile C et al.
Human Mutation, 2009
Penetrance of LGI1 mutations in autosomal dominant partial epilepsy with auditory features.
Rosanoff MJ et al.
Neurology, 2008
Genetic etiology of new forms of familial epilepsy.
Wang X et al.
Frontiers in Bioscience : a Journal and Virtual Library, 2008
Two novel epilepsy-linked mutations leading to a loss of function of LGI1.
Chabrol E et al.
Archives of Neurology, 2007
Select a paper to view details