Associated Papers
Phenylbutyrate for monogenetic epilepsy: Literature review.
Stone A et al.
Epilepsy Research, 2025
Biallelic LGI1 and ADAM23 variants cause hippocampal epileptic encephalopathy via the LGI1-ADAM22/23 pathway.
Hirano Y et al.
Brain : a Journal of Neurology, 2025
Structural insights into heterohexameric assembly of epilepsy-related ligand-receptor complex LGI1-ADAM22.
Yamaguchi T et al.
Elife, 2025
Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity.
Miyazaki Y et al.
Cell Reports, 2024
A patient-derived mutation of epilepsy-linked LGI1 increases seizure susceptibility through regulating Kv1.1.
Zhou L et al.
Cell & Bioscience, 2023
A novel LGI1 mutation causing autosomal dominant lateral temporal lobe epilepsy confirmed by a precise knock-in mouse model.
Hu P et al.
Cns Neuroscience & Therapeutics, 2022
The LGI1 protein: molecular structure, physiological functions and disruption-related seizures.
Baudin P et al.
Cellular and Molecular Life Sciences : Cmls, 2021
Characterizing the molecular etiology of arthrogryposis multiplex congenita in patients with LGI4 mutations.
Booth DG et al.
Glia, 2021
Insights into the mechanisms of epilepsy from structural biology of LGI1-ADAM22.
Yamagata A et al.
Cellular and Molecular Life Sciences : Cmls, 2020
Structural insights into leucine-rich repeat-containing synaptic cleft molecules.
Yamagata A et al.
Current Opinion in Structural Biology, 2019
Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.
Yamagata A et al.
Nature Communications, 2018
Celecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy.
Zhou L et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2018
Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretation.
Traynelis J et al.
Genome Research, 2017
ExACtly zero or once: A clinically helpful guide to assessing genetic variants in mild epilepsies.
Bennett CA et al.
Neurology. Genetics, 2017
The LGI1-ADAM22 protein complex in synaptic transmission and synaptic disorders.
Fukata Y et al.
Neuroscience Research, 2017
Genetic models of focal epilepsies.
Boillot M et al.
Journal of Neuroscience Methods, 2016
Screening LGI1 in a cohort of 26 lateral temporal lobe epilepsy patients with auditory aura from Turkey detects a novel de novo mutation.
Kesim YF et al.
Epilepsy Research, 2016
Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.
Yokoi N et al.
Nature Medicine, 2015
K(+) channelepsy: progress in the neurobiology of potassium channels and epilepsy.
D'Adamo MC et al.
Frontiers in Cellular Neuroscience, 2013
A rat model for LGI1-related epilepsies.
Baulac S et al.
Human Molecular Genetics, 2012
A computational model of the LGI1 protein suggests a common binding site for ADAM proteins.
Leonardi E et al.
Plos One, 2011
Similarity of molecular phenotype between known epilepsy gene LGI1 and disease candidate gene LGI2.
Limviphuvadh V et al.
Bmc Biochemistry, 2010
Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy.
Fukata Y et al.
Proceedings of the National Academy of Sciences of the United States of America, 2010
LGI1 mutations in autosomal dominant and sporadic lateral temporal epilepsy.
Nobile C et al.
Human Mutation, 2009
Penetrance of LGI1 mutations in autosomal dominant partial epilepsy with auditory features.
Rosanoff MJ et al.
Neurology, 2008
Somatic alterations in brain tumors.
Barnholtz-Sloan J et al.
Oncology Reports, 2008
Genetic etiology of new forms of familial epilepsy.
Wang X et al.
Frontiers in Bioscience : a Journal and Virtual Library, 2008
The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface.
Sirerol-Piquer MS et al.
Human Molecular Genetics, 2006
ADPEAF mutations reduce levels of secreted LGI1, a putative tumor suppressor protein linked to epilepsy.
Senechal KR et al.
Human Molecular Genetics, 2005
LGI1: a gene involved in epileptogenesis and glioma progression?
Gu W et al.
Neurogenetics, 2005
Autosomal dominant lateral temporal epilepsy: clinical spectrum, new epitempin mutations, and genetic heterogeneity in seven European families.
Michelucci R et al.
Epilepsia, 2003
Novel LGI1 mutation in a family with autosomal dominant partial epilepsy with auditory features.
Fertig E et al.
Neurology, 2003
Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features.
Kalachikov S et al.
Nature Genetics, 2002