Associated Papers
Asparagine endopeptidase cleaves apolipoprotein A1 and accelerates pathogenesis of atherosclerosis.
Wang M et al.
The Journal of Clinical Investigation, 2025
Vimentin Fragmentation and Its Role in Amyloid-Beta Plaque Deposition in Alzheimer's Disease.
Zhang L et al.
International Journal of Molecular Sciences, 2025
EBP1 potentiates amyloid β pathology by regulating γ-secretase.
Kim BS et al.
Nature Aging, 2025
Bridging integrator 1 fragment accelerates tau aggregation and propagation by enhancing clathrin-mediated endocytosis in mice.
Zhang X et al.
Plos Biology, 2024
AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments.
Zhang W et al.
The Journal of Clinical Investigation, 2023
Delta- and beta- secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer's disease.
Xia Y et al.
Progress in Neurobiology, 2021
A γ-adducin cleavage fragment induces neurite deficits and synaptic dysfunction in Alzheimer's disease.
Xiong M et al.
Progress in Neurobiology, 2021
Role of Asparagine Endopeptidase in Mediating Wild-Type p53 Inactivation of Glioblastoma.
Lin Y et al.
Journal of the National Cancer Institute, 2020
δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities.
Zhang Z et al.
Translational Neurodegeneration, 2020
Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease.
Wang ZH et al.
Cell Reports, 2019
Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies.
Wang ZH et al.
The Journal of Experimental Medicine, 2018
C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease.
Wang ZH et al.
Nature Communications, 2018
Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease.
Zhang Z et al.
Nature Structural & Molecular Biology, 2017
Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.
Zhang Z et al.
Nature Medicine, 2014
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