Varaico: Literature-Extracted Genetic Variants

Gene:LIPG
Variant:p.T111I
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LIPG

NM_006033.4:p.T111I

Associated Papers

The effect of dulaglutide on glycated hemoglobin is associated with PNPLA3 Ι148Μ gene polymorphism in patients with type 2 diabetes mellitus.

Gavriilidis S et al.

Endocrine, 2025

Endothelial lipase variant T111I does not alter inhibition by angiopoietin-like proteins.

Sylvers-Davie KL et al.

Scientific Reports, 2024

Endothelial Lipase Variant, T111I, Does Not Alter Inhibition by Angiopoietin-like Proteins.

Sylvers-Davie KL et al.

Biorxiv : the Preprint Server for Biology, 2023

Effect of genetic variations in drug transporters, metabolizing enzyme and regulatory genes on the development of HIV-associated lipodystrophy.

Shyamveer et al.

The Journal of Gene Medicine, 2023

Decoding the genetic relationship between Alzheimer's disease and type 2 diabetes: potential risk variants and future direction for North Africa.

Boukhalfa W et al.

Frontiers in Aging Neuroscience, 2023

37342358 (PubMed )
Supplement: Table_2.XLSX › Table_2_SNPnexus_annotation

Interplay of physical activity and genetic variants of the endothelial lipase on cardiovascular disease risk factors.

Salazar-Tortosa DF et al.

Pediatric Research, 2022

Significant association between the endothelial lipase gene 584C/T polymorphism and coronary artery disease risk.

Wu YE et al.

Bioscience Reports, 2020

Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance.

Adam RC et al.

Journal of Lipid Research, 2020

Gene polymorphism associated with angiotensinogen (M235T), endothelial lipase (584C/T) and susceptibility to coronary artery disease: a meta-analysis.

Zhao H et al.

Bioscience Reports, 2020

Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.

Lu X et al.

Nature Genetics, 2017

HDL Cholesterol Metabolism and the Risk of CHD: New Insights from Human Genetics.

Vitali C et al.

Current Cardiology Reports, 2017

Association of the CETP Taq1B and LIPG Thr111Ile Polymorphisms with Glycated Hemoglobin and Blood Lipids in Newly Diagnosed Hyperlipidemic Patients.

Agapakis D et al.

Canadian Journal of Diabetes, 2016

Coding-sequence variants are associated with blood lipid levels in 14,473 Chinese.

Lu X et al.

Human Molecular Genetics, 2016

Association of endothelial lipase Thr111Ile polymorphism with proliferative retinopathy in type 2 diabetes patients.

Arndt C et al.

Diabetes & Metabolism, 2014

Flow-mediated dilation, carotid wall thickness and HDL function in subjects with hyperalphalipoproteinemia.

Vigna GB et al.

Nutrition, Metabolism, and Cardiovascular Diseases : Nmcd, 2014

Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk.

Holmen OL et al.

Nature Genetics, 2014

24633158 (PubMed )
Supplement: NIHMS570373-supplement-1.pdf

Lack of association between a common polymorphism of the endothelial lipase gene and early-onset coronary artery disease in a Chinese Han population.

Cai GJ et al.

Genetics and Molecular Research : Gmr, 2014

Somatic signature of brain-specific single nucleotide variations in sporadic Alzheimer's disease.

Parcerisas A et al.

Journal of Alzheimer's Disease : Jad, 2014

25024348 (PubMed )
Supplement: sj-xls-6-alz-10.3233_jad-140891.xls › P1H

Monogenic causes of elevated HDL cholesterol and implications for development of new therapeutics.

Larach DB et al.

Clinical Lipidology, 2013

The impact of partial and complete loss-of-function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans.

Singaraja RR et al.

Circulation. Cardiovascular Genetics, 2013

Genetic and structure-function studies of missense mutations in human endothelial lipase.

Razzaghi H et al.

Plos One, 2013

The association between endothelial lipase -384A/C gene polymorphism and acute coronary syndrome in a Chinese population.

Cai G et al.

Molecular Biology Reports, 2012

Population-Based Resequencing of LIPG and ZNF202 Genes in Subjects with Extreme HDL Levels.

Razzaghi H et al.

Frontiers in Genetics, 2012

Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol.

Tietjen I et al.

Plos One, 2012

Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol.

Khetarpal SA et al.

Plos Genetics, 2011

Interactions of the LIPG 584C>T polymorphism and alcohol consumption on serum lipid levels.

Liu WY et al.

Alcohol (fayetteville, N.y.), 2011

Association of endothelial lipase Thr111Ile polymorphism with lipid metabolism and microvascular complications in type 2 diabetic patients.

Durlach V et al.

Diabetes & Metabolism, 2011

Association of the LIPG 584C > T polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations.

Liu WY et al.

Lipids in Health and Disease, 2010

Lack of association between common genetic variation in endothelial lipase (LIPG) and the risk for CAD and DVT.

Vergeer M et al.

Atherosclerosis, 2010

Role of endothelial lipase in atherosclerosis.

Huang J et al.

Translational Research : the Journal of Laboratory and Clinical Medicine, 2010

Interaction of common sequence variants and selected risk factors in determination of HDL cholesterol levels.

Katerina H et al.

Clinical Biochemistry, 2010

Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis.

Chen SN et al.

Bmc Medical Genetics, 2009

19878569 (PubMed )
Supplement: 1471-2350-10-111-S1.pdf

Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study.

Smith CE et al.

Atherosclerosis, 2009

The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations.

Jensen MK et al.

European Heart Journal, 2009

Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans.

Edmondson AC et al.

The Journal of Clinical Investigation, 2009

Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.

Boes E et al.

Experimental Gerontology, 2009

Evaluation of resequencing on number of tag SNPs of 13 atherosclerosis-related genes in Thai population.

Tocharoentanaphol C et al.

Journal of Human Genetics, 2008

[Association of the MspI polymorphism of cytochrome P4501A1 gene and smoking to the susceptibility to coronary artery disease].

Zhang XM et al.

Zhonghua Xin Xue Guan Bing Za Zhi, 2007

Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase.

Shimamura M et al.

Arteriosclerosis, Thrombosis, and Vascular Biology, 2007

Genetic factors for obesity.

Yamada Y et al.

International Journal of Molecular Medicine, 2006

Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis.

Yamaguchi S et al.

International Journal of Molecular Medicine, 2006

Assessment of genetic factors for type 2 diabetes mellitus.

Yamada Y et al.

International Journal of Molecular Medicine, 2006

Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans.

Hutter CM et al.

Atherosclerosis, 2006

Higher order lipase gene association with plasma triglycerides.

Reilly MP et al.

Journal of Lipid Research, 2005

High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men.

Deguchi H et al.

Circulation, 2005

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