Associated Papers
Transcriptional profiling of Hutchinson-Gilford progeria patients identifies primary target pathways of progerin.
Vidak S et al.
Nucleus (austin, Tex.), 2026
Telomere shortening in laminopathic dilated cardiomyopathy.
Chang ACY et al.
Npj Regenerative Medicine, 2026
Gene-based Therapies for Genetic Cardiomyopathies: Molecular Medicine for Heart Disease.
Sharma S et al.
The Canadian Journal of Cardiology, 2026
The unfolded protein response in progeria arteries originates from non-endothelial cell types.
Silva RA et al.
Life Science Alliance, 2026
GA4GH phenopacket-driven characterization of genotype-phenotype correlations in Mendelian disorders.
Rekerle L et al.
American Journal of Human Genetics, 2026
Vascular cell types in progeria: victims or villains?
Benedicto I et al.
Trends in Molecular Medicine, 2026
Lipid Metabolism Alterations in Hereditary Inorganic Pyrophosphate Deficiency Syndromes: A Narrative Review of Insights and Controversies.
Derudder R et al.
Journal of Inherited Metabolic Disease, 2026
Selection of specific and efficient siRNAs in new cellular model for Hutchinson-Gilford progeria syndrome therapy.
Dzianisava V et al.
Molecular Therapy. Nucleic Acids, 2025
Lonafarnib Clinical Trials Demonstrate Uncoupling of the Muscle-Bone Unit in Hutchinson-Gilford Progeria Syndrome.
Kreienkamp RJ et al.
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 2025
Baricitinib Augments Lonafarnib Therapy to Preserve Colonic Homeostasis and Microbial Balance in a Mouse Model of Progeria.
Schroll M et al.
Aging Cell, 2025
miR-140-5p Overexpression Contributes to Oxidative Stress and Mitochondrial Dysfunction in Hutchinson-Gilford Progeria Syndrome Fibroblasts Through NRF2 Pathway.
Toury L et al.
Aging Cell, 2025
Vascular organoid model of Hutchinson-Gilford progeria syndrome uncovers repression of the SRF pathway in premature aging.
Sun X et al.
Developmental Cell, 2025
The systemic wrinkled skin phenotype involves aberrant expression and variation of genes related to the oxidative stress and extracellular matrix in Xiang pigs.
Hu F et al.
Bmc Genomics, 2025
The Converging Roles of Nucleases and Helicases in Genome Maintenance and the Aging Process.
Margariti A et al.
Life (basel, Switzerland), 2025
LMNA-related cardiomyopathy: From molecular pathology to cardiac gene therapy.
Wang Z et al.
Journal of Advanced Research, 2025
Counteracting lysosome defects alleviates the cellular senescence of Hutchinson-Gilford progeria syndrome.
Wang X et al.
Science China. Life Sciences, 2025
Genetically Confirmed Familial Case of Nonsyndromic Cardiac Progeria Caused by the LMNA p.Asp300Asn Variant with Presumed Gonadal Mosaicism: Phenotypic Comparison with Previously Reported Patients.
Nuzhnaya E et al.
Genes, 2025
POLR3A mutations cause nucleolus abnormalities and aberrant telomerase RNA metabolism in induced pluripotent stem cells from Wiedemann-Rautenstrauch premature aging syndrome patient.
Orlova EA et al.
Biogerontology, 2025
Rare case of longevity in Hutchinson-Gilford progeria syndrome and literature review.
Cai XL et al.
Orphanet Journal of Rare Diseases, 2025
Manipulation of the nucleoscaffold potentiates cellular reprogramming kinetics.
Yang BA et al.
Pnas Nexus, 2025
Generation of Nonintegrative-Induced Pluripotent Stem Cells in Hutchinson-Gilford Progeria Syndrome: Enhancing Aging Research.
Kadiwala J et al.
Aging Medicine (milton (n.s.w)), 2025
A longevity-associated variant of the human BPIFB4 gene prevents diastolic dysfunction in progeria mice.
Qiu Y et al.
Signal Transduction and Targeted Therapy, 2025
Unraveling the mysteries of Hutchinson-Gilford progeria syndrome: a comprehensive review of LMNA gene mutations.
Zhou X et al.
Biogerontology, 2025
Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin.
Vidak S et al.
Biorxiv : the Preprint Server for Biology, 2025
Genomic insights into the demographic history and local adaptation of wild boars across Eurasia.
Wang Z et al.
Cell Genomics, 2025
Precise progerin targeting using RfxCas13d: A therapeutic avenue for Hutchinson-Gilford progeria syndrome.
Chae U et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy, 2025
Therapeutic RNA cleavage with RfxCas13d in Hutchinson-Gilford progeria syndrome.
Zheng C
Molecular Therapy : the Journal of the American Society of Gene Therapy, 2025
Patient-Derived Cortical Organoids Reveal Senescence of Neural Progenitor Cells in Hutchinson-Gilford Progeria Syndrome.
Jeon S et al.
Aging Cell, 2025
Involvement of NRF2 and AMPK signaling in aging and progeria: a digest.
Petsouki E et al.
Redox Biology, 2025
ClinGen Variant Curation Interface Workshops: Training Variant Scientists on an International Platform.
Ritter DI et al.
Medrxiv : the Preprint Server for Health Sciences, 2025
Deregulated miR-145 and miR-27b in Hutchinson-Gilford progeria syndrome: implications for adipogenesis.
Fenzl FQ et al.
Aging, 2025
Nicotinamide Mononucleotide Alleviates Aging Defects in Hutchinson-Gilford Progeria Syndrome.
Xu Y et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2025
Impact of miR-181a on SIRT1 Expression and Senescence in Hutchinson-Gilford Progeria Syndrome.
Lederer EM et al.
Diseases (basel, Switzerland), 2025
A noncanonical cGAS-STING pathway drives cellular and organismal aging.
Cancado de Faria R et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025
National survey of Hutchinson-Gilford progeria syndrome and progeroid laminopathy in Japan.
Okawa Y et al.
Aging, 2025
Sclerotic skin in Hutchinson-Gilford progeria syndrome: Reversible senescent phenotype.
Kwak D et al.
Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : Jddg, 2025
Assessing the Efficacy of Small Molecule Drugs in Hutchinson-Gilford Progeria Syndrome: A Review of Clinical Trials.
Desai D et al.
Reviews on Recent Clinical Trials, 2025
The anti-senescence effect of D-β-hydroxybutyrate in Hutchinson-Gilford progeria syndrome involves progerin clearance by the activation of the AMPK-mTOR-autophagy pathway.
Monterrubio-Ledezma F et al.
Geroscience, 2025
Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease.
Revêchon G et al.
Nature Aging, 2025
Investigating telomere length in progeroid syndromes: implications for aging disorders.
Srour L et al.
Aging, 2025
RNA-coupled CRISPR Screens Reveal ZNF207 as a Regulator of LMNA Aberrant Splicing in Progeria.
Behera AK et al.
Biorxiv : the Preprint Server for Biology, 2025
Mesenchymal Stem Cell Therapy for Hutchinson-Gilford Progeria: Improvements in Arterial Stiffness and Bone Mineral Density in a Single Case.
Joo EY et al.
Children (basel, Switzerland), 2025
Adenine base editing rescues pathogenic phenotypes in tissue engineered vascular model of Hutchinson-Gilford progeria syndrome.
Abutaleb NO et al.
Apl Bioengineering, 2025