Associated Papers
Stem cell-associated osteogenic deficiency causes craniofacial deformities with progeroid accumulation of prelamin A.
Li K et al.
Jci Insight, 2026
Prelamin A Does Not Promote Atherosclerosis or Vascular Smooth Muscle Loss.
Wang Y et al.
Biorxiv : the Preprint Server for Biology, 2025
Genetic and pharmacological modulation of lamin A farnesylation determines its function and turnover.
Foo MXR et al.
Aging Cell, 2024
Prelamin A and ZMPSTE24 in premature and physiological aging.
Worman HJ et al.
Nucleus (austin, Tex.), 2023
Impaired end joining induces cardiac atrophy in a Hutchinson-Gilford progeria mouse model.
Chen Y et al.
Proceedings of the National Academy of Sciences of the United States of America, 2023
Mineralocorticoid Receptor Antagonism Prevents Type 2 Familial Partial Lipodystrophy Brown Adipocyte Dysfunction.
Schena E et al.
Cells, 2023
Overview of cellular homeostasis-associated nuclear envelope lamins and associated input signals.
Kim HJ et al.
Frontiers in Cell and Developmental Biology, 2023
Filamentous nuclear actin regulation of PML NBs during the DNA damage response is deregulated by prelamin A.
Cobb AM et al.
Cell Death & Disease, 2022
Progerin modulates the IGF-1R/Akt signaling involved in aging.
Jiang B et al.
Science Advances, 2022
Mechanisms of A-Type Lamin Targeting to Nuclear Ruptures Are Disrupted in LMNA- and BANF1-Associated Progerias.
Sears RM et al.
Cells, 2022
Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice.
Wang Y et al.
Proceedings of the National Academy of Sciences of the United States of America, 2022
The role of prelamin A post-translational maturation in stress response and 53BP1 recruitment.
Capanni C et al.
Frontiers in Cell and Developmental Biology, 2022
Preclinical Advances of Therapies for Laminopathies.
Benarroch L et al.
Journal of Clinical Medicine, 2021
Protein structural and mechanistic basis of progeroid laminopathies.
Marcelot A et al.
The Febs Journal, 2021
Mutations Involved in Premature-Ageing Syndromes.
Coppedè F
The Application of Clinical Genetics, 2021
Lamin A involvement in ageing processes.
Cenni V et al.
Ageing Research Reviews, 2020
PCAF Involvement in Lamin A/C-HDAC2 Interplay during the Early Phase of Muscle Differentiation.
Santi S et al.
Cells, 2020
Prelamin A mediates myocardial inflammation in dilated and HIV-associated cardiomyopathies.
Brayson D et al.
Jci Insight, 2019
Complex effects of laminopathy mutations on nuclear structure and function.
Ho R et al.
Clinical Genetics, 2019
Statins and Histone Deacetylase Inhibitors Affect Lamin A/C - Histone Deacetylase 2 Interaction in Human Cells.
Mattioli E et al.
Frontiers in Cell and Developmental Biology, 2019
ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability.
Spear ED et al.
Disease Models & Mechanisms, 2018
Autophagic Removal of Farnesylated Carboxy-Terminal Lamin Peptides.
Lu X et al.
Cells, 2018
Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing.
Cenni V et al.
Ageing Research Reviews, 2018
Laminopathy-causing lamin A mutations reconfigure lamina-associated domains and local spatial chromatin conformation.
Briand N et al.
Nucleus (austin, Tex.), 2018
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
Brull A et al.
Frontiers in Physiology, 2018
Chrom3D: three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts.
Paulsen J et al.
Genome Biology, 2017
A Novel Lamin A Mutant Responsible for Congenital Muscular Dystrophy Causes Distinct Abnormalities of the Cell Nucleus.
Barateau A et al.
Plos One, 2017
Emery-Dreifuss Muscular Dystrophy-Associated Mutant Forms of Lamin A Recruit the Stress Responsive Protein Ankrd2 into the Nucleus, Affecting the Cellular Response to Oxidative Stress.
Angori S et al.
Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 2017
Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient.
Cobb AM et al.
Aging Cell, 2016
Disruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling.
Cobb AM et al.
Nucleus (austin, Tex.), 2016
LMNA missense mutations causing familial partial lipodystrophy do not lead to an accumulation of prelamin A.
Tu Y et al.
Nucleus (austin, Tex.), 2016
A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder.
Wang Y et al.
Journal of Cell Science, 2016
Mutant lamin A links prophase to a p53 independent senescence program.
Moiseeva O et al.
Cell Cycle (georgetown, Tex.), 2015
Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: understanding the osteolytic process triggered by altered lamins.
Evangelisti C et al.
Oncotarget, 2015
The p.R482W substitution in A-type lamins deregulates SREBP1 activity in Dunnigan-type familial partial lipodystrophy.
Vadrot N et al.
Human Molecular Genetics, 2015
New look at the role of progerin in skin aging.
Skoczyńska A et al.
Przeglad Menopauzalny = Menopause Review, 2015
Systematic identification of pathological lamin A interactors.
Dittmer TA et al.
Molecular Biology of the Cell, 2014
The protein kinase Akt/PKB regulates both prelamin A degradation and Lmna gene expression.
Bertacchini J et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2013
Familial partial lipodystrophy, mandibuloacral dysplasia and restrictive dermopathy feature barrier-to-autointegration factor (BAF) nuclear redistribution.
Capanni C et al.
Cell Cycle (georgetown, Tex.), 2012
Requirements for efficient proteolytic cleavage of prelamin A by ZMPSTE24.
Barrowman J et al.
Plos One, 2012
Subcellular localization of SREBP1 depends on its interaction with the C-terminal region of wild-type and disease related A-type lamins.
Duband-Goulet I et al.
Experimental Cell Research, 2011
Prelamin A-mediated recruitment of SUN1 to the nuclear envelope directs nuclear positioning in human muscle.
Mattioli E et al.
Cell Death and Differentiation, 2011
Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice.
Oh YS et al.
Aging Cell, 2010
Lamin A precursor induces barrier-to-autointegration factor nuclear localization.
Capanni C et al.
Cell Cycle (georgetown, Tex.), 2010
Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging.
Ragnauth CD et al.
Circulation, 2010
Emerin-prelamin A interplay in human fibroblasts.
Capanni C et al.
Biology of the Cell, 2009