Associated Papers
Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz (Wwtr1) Activation in Male LDLR-/- Mice.
Behrmann A et al.
Endocrinology, 2023
Whole Exome/Genome Sequencing Joint Analysis of a Family with Oligogenic Familial Hypercholesterolemia.
Ghaleb Y et al.
Metabolites, 2022
TCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut-liver crosstalk.
Bhat N et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2022
Wnt5a Promotes Lysosomal Cholesterol Egress and Protects Against Atherosclerosis.
Awan S et al.
Circulation Research, 2022
RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.
Belenguer G et al.
Nature Communications, 2022
WNT3A rs752107(C > T) Polymorphism Is Associated With an Increased Risk of Essential Hypertension and Related Cardiovascular Diseases.
Ren H et al.
Frontiers in Cardiovascular Medicine, 2021
Regulation of the Low-Density Lipoprotein Receptor-Related Protein LRP6 and Its Association With Disease: Wnt/β-Catenin Signaling and Beyond.
Jeong W et al.
Frontiers in Cell and Developmental Biology, 2021
Lrp6 Genotype affects Individual Susceptibility to Nonalcoholic Fatty Liver Disease and Silibinin Therapeutic Response via Wnt/β-catenin-Cyp2e1 Signaling.
Chen LJ et al.
International Journal of Biological Sciences, 2021
The rs2302685 polymorphism in the LRP6 gene is associated with bone mineral density and body composition in Iranian children.
Montazeri-Najafabady N et al.
The Journal of Gene Medicine, 2020
Lipoprotein receptor signalling in atherosclerosis.
Mineo C
Cardiovascular Research, 2020
The interplay of canonical and noncanonical Wnt signaling in metabolic syndrome.
Abou Ziki MD et al.
Nutrition Research (new York, N.y.), 2019
The association of LRP6 rs2302685 (V1062I) polymorphism with the risk of hyperlipidemia in Iranian children and adolescents.
Montazeri-Najafabady N et al.
Annals of Human Genetics, 2018
Harnessing low-density lipoprotein receptor protein 6 (LRP6) genetic variation and Wnt signaling for innovative diagnostics in complex diseases.
Wang ZM et al.
The Pharmacogenomics Journal, 2018
Mutant LRP6 Impairs Endothelial Cell Functions Associated with Familial Normolipidemic Coronary Artery Disease.
Guo J et al.
International Journal of Molecular Sciences, 2016
Metabolic syndrome: genetic insights into disease pathogenesis.
Abou Ziki MD et al.
Current Opinion in Lipidology, 2016
Characterization of Disease-Associated Mutations in Human Transmembrane Proteins.
Molnár J et al.
Plos One, 2016
Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease.
Srivastava R et al.
Cell Reports, 2015
Nonalcoholic fatty liver disease induced by noncanonical Wnt and its rescue by Wnt3a.
Wang S et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2015
Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) Is a Novel Nutritional Therapeutic Target for Hyperlipidemia, Non-Alcoholic Fatty Liver Disease, and Atherosclerosis.
Go GW
Nutrients, 2015
Wnt signaling, de novo lipogenesis, adipogenesis and ectopic fat.
Song K et al.
Oncotarget, 2014
The LRP6 rs2302685 polymorphism is associated with increased risk of myocardial infarction.
Xu S et al.
Lipids in Health and Disease, 2014
The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.
Go GW et al.
Cell Metabolism, 2014
LRP6 in mesenchymal stem cells is required for bone formation during bone growth and bone remodeling.
Li C et al.
Bone Research, 2014
Rare nonconservative LRP6 mutations are associated with metabolic syndrome.
Singh R et al.
Human Mutation, 2013
A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice.
Maupin KA et al.
Bone Research, 2013
LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans.
Singh R et al.
Cell Metabolism, 2013
LRP5 and LRP6 in development and disease.
Joiner DM et al.
Trends in Endocrinology and Metabolism: Tem, 2013
Low-density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasis.
Go GW et al.
The Yale Journal of Biology and Medicine, 2012
LRP6 protein regulates low density lipoprotein (LDL) receptor-mediated LDL uptake.
Ye ZJ et al.
The Journal of Biological Chemistry, 2012
Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.
Ahn VE et al.
Developmental Cell, 2011
Modulation of canonical Wnt signaling by the extracellular matrix component biglycan.
Berendsen AD et al.
Proceedings of the National Academy of Sciences of the United States of America, 2011
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1.
Cheng Z et al.
Nature Structural & Molecular Biology, 2011
Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611C increases PDGF-dependent vascular smooth muscle cell proliferation.
Keramati AR et al.
Proceedings of the National Academy of Sciences of the United States of America, 2011
Carotid artery atherosclerosis in hypertensive patients with a functional LDL receptor-related protein 6 gene variant.
Sarzani R et al.
Nutrition, Metabolism, and Cardiovascular Diseases : Nmcd, 2011
Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance.
Liu W et al.
Circulation Research, 2008
Association study of the effect of WFS1 polymorphisms on risk of type 2 diabetes in Japanese population.
Mita M et al.
The Kobe Journal of Medical Sciences, 2008
Lack of association of LRP5 and LRP6 polymorphisms with type 2 diabetes mellitus in the Japanese population.
Zenibayashi M et al.
Endocrine Journal, 2008
Msx2 exerts bone anabolism via canonical Wnt signaling.
Cheng SL et al.
The Journal of Biological Chemistry, 2008
Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease.
De Ferrari GV et al.
Proceedings of the National Academy of Sciences of the United States of America, 2007
LRP6 mutation in a family with early coronary disease and metabolic risk factors.
Mani A et al.
Science (new York, N.y.), 2007