Varaico: Literature-Extracted Genetic Variants

Gene:LRRK1
Variant:p.D1409A
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LRRK1

NM_024652.6:p.D1409A

Associated Papers

BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM.

Hanna MG et al.

The Embo Journal, 2025

BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM.

Hanna MG et al.

Biorxiv : the Preprint Server for Biology, 2025

39386594 (PubMed )
Supplement: NIHPP2024.09.28.615015v3-supplement-1.pdf

Structure of LRRK1 and mechanisms of autoinhibition and activation.

Reimer JM et al.

Nature Structural & Molecular Biology, 2023

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.

Malik AU et al.

The Biochemical Journal, 2022

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.

Malik AU et al.

The Biochemical Journal, 2021

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."