Associated Papers
Roc, the G-domain of the Parkinson's disease-associated protein LRRK2.
Park Y et al.
Trends in Biochemical Sciences, 2022
The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization.
Lara Ordóñez AJ et al.
Biology Open, 2022
Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity.
Nguyen APT et al.
Proceedings of the National Academy of Sciences of the United States of America, 2020
LRRK2 interacts with the vacuolar-type H+-ATPase pump a1 subunit to regulate lysosomal function.
Wallings R et al.
Human Molecular Genetics, 2019
The Parkinson's disease-associated mutation N1437H impairs conformational dynamics in the G domain of LRRK2.
Huang X et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2019
The Enzymatic Core of the Parkinson's Disease-Associated Protein LRRK2 Impairs Mitochondrial Biogenesis in Aging Yeast.
Aufschnaiter A et al.
Frontiers in Molecular Neuroscience, 2018
GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.
Blanca Ramírez M et al.
Human Molecular Genetics, 2017
LRRK2: from kinase to GTPase to microtubules and back.
Blanca Ramírez M et al.
Biochemical Society Transactions, 2017
Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.
Islam MS et al.
Biochemical Society Transactions, 2017
Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.
Nguyen AP et al.
Advances in Neurobiology, 2017
Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.
Nixon-Abell J et al.
Frontiers in Molecular Neuroscience, 2016
G2385R and I2020T Mutations Increase LRRK2 GTPase Activity.
Ho DH et al.
Biomed Research International, 2016
The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.
Imai Y et al.
Plos Genetics, 2015
Modeling LRRK2 Pathobiology in Parkinson's Disease: From Yeast to Rodents.
Daniel G et al.
Current Topics in Behavioral Neurosciences, 2015
Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications.
Rudenko IN et al.
Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics, 2014
GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2.
Biosa A et al.
Human Molecular Genetics, 2013
GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1.
Stafa K et al.
Plos Genetics, 2012
On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies.
Daniëls V et al.
Neuro-signals, 2011
GTPase activity plays a key role in the pathobiology of LRRK2.
Xiong Y et al.
Plos Genetics, 2010
Contribution of GTPase activity to LRRK2-associated Parkinson disease.
Tsika E et al.
Small Gtpases, 0