Associated Papers
Targeting specific kinase substrates rescues increased colitis severity induced by the Crohn's disease-linked LRRK2-N2081D variant.
Heaton GR et al.
The Journal of Clinical Investigation, 2025
Regulation of LRRK2 activity by metabolic stress and heavy metal exposure.
Kentros M et al.
Brain Research, 2025
Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson's disease.
Gregori M et al.
The Journal of Cell Biology, 2025
Roles of LRRK2 and its orthologs in protecting against neurodegeneration and neurodevelopmental defects.
Nguyen APT et al.
Frontiers in Cell and Developmental Biology, 2025
Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase-dependent mechanism.
Gilsbach BK et al.
Elife, 2024
Targeting Specific Kinase Substrates Rescues Increased Colitis Severity Induced by the Crohn's Disease-Linked LRRK2-N2081D Variant.
Heaton GR et al.
Biorxiv : the Preprint Server for Biology, 2024
Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization.
Pathak P et al.
Acs Chemical Neuroscience, 2023
Pathogenic LRRK2 compromises the subcellular distribution of lysosomes in a Rab12-RILPL1-dependent manner.
Ito K et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2023
Upregulation of LRRK2 following traumatic brain injury does not directly phosphorylate Thr175 tau.
Donison N et al.
Frontiers in Cellular Neuroscience, 2023
Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis.
Weindel CG et al.
Cell, 2022
The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization.
Lara Ordóñez AJ et al.
Biology Open, 2022
Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment.
Kluss JH et al.
Neurobiology of Disease, 2022
Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement.
Fdez E et al.
Iscience, 2022
Exploring the focal role of LRRK2 kinase in Parkinson's disease.
Kumar S et al.
Environmental Science and Pollution Research International, 2022
LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson's disease.
Pang SY et al.
Translational Neurodegeneration, 2022
Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
Mamais A et al.
Plos Biology, 2021
Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo.
Sarkar S et al.
Molecular Neurodegeneration, 2021
Generation of fourteen isogenic cell lines for Parkinson's disease-associated leucine-rich repeat kinase (LRRK2).
Beylina A et al.
Stem Cell Research, 2021
Preclinical modeling of chronic inhibition of the Parkinson's disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo.
Kluss JH et al.
Molecular Neurodegeneration, 2021
LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination-mediated DNA double strand break repair.
Chen L et al.
Clinical and Translational Medicine, 2021
Multiple Pathways of LRRK2-G2019S/Rab10 Interaction in Dopaminergic Neurons.
Fellgett A et al.
Journal of Parkinson's Disease, 2021
LRRK2 mediates tubulation and vesicle sorting from lysosomes.
Bonet-Ponce L et al.
Science Advances, 2020
Pathogenic LRRK2 requires secondary factors to induce cellular toxicity.
Lobbestael E et al.
Bioscience Reports, 2020
Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity.
Nguyen APT et al.
Proceedings of the National Academy of Sciences of the United States of America, 2020
The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network.
Beilina A et al.
Cell Reports, 2020
LRRK2 Phosphorylation, More Than an Epiphenomenon.
Marchand A et al.
Frontiers in Neuroscience, 2020
LRRK2 and Protein Aggregation in Parkinson's Disease: Insights From Animal Models.
Dues DJ et al.
Frontiers in Neuroscience, 2020
Progress in LRRK2-Associated Parkinson's Disease Animal Models.
Seegobin SP et al.
Frontiers in Neuroscience, 2020
The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson's Disease.
Rideout HJ et al.
Frontiers in Neuroscience, 2020
RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits.
Lara Ordónez AJ et al.
Human Molecular Genetics, 2019
Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites.
Marte A et al.
Journal of Neurochemistry, 2019
The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain.
Schmidt SH et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019
Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2.
Langston RG et al.
Neurochemical Research, 2019
Understanding the role of genetic variability in LRRK2 in Indian population.
Kishore A et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2019
Vitamin B12 modulates Parkinson's disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection.
Schaffner A et al.
Cell Research, 2019
The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A.
Rivero-Ríos P et al.
The Journal of Biological Chemistry, 2019
Autophagy and LRRK2 in the Aging Brain.
Albanese F et al.
Frontiers in Neuroscience, 2019
Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics.
Bardai FH et al.
Plos Biology, 2018
LRRK2 Phosphorylation: Behind the Scenes.
De Wit T et al.
The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry, 2018