Associated Papers
RedOx regulation of LRRK2 kinase activity by active site cysteines.
Trilling CR et al.
Npj Parkinson's Disease, 2024
Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2.
Schmidt SH et al.
Proceedings of the National Academy of Sciences of the United States of America, 2021
Structure of LRRK2 in Parkinson's disease and model for microtubule interaction.
Deniston CK et al.
Nature, 2020
LRRK2 Phosphorylation, More Than an Epiphenomenon.
Marchand A et al.
Frontiers in Neuroscience, 2020
Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery.
Taylor SS et al.
Frontiers in Molecular Neuroscience, 2020
The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain.
Schmidt SH et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019
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