Associated Papers
TBK1 activity regulates the directionality of axonal transport of signalling endosomes.
Villarroel-Campos D et al.
Life Science Alliance, 2026
Investigating the Genetic Relationship Between Vitamin B12 Metabolism and Parkinson Disease.
Dering R et al.
Neurology. Genetics, 2026
No evidence for the LRRK2 p.L1795F variant in a Southern Italian cohort with Parkinson's disease.
Gagliardi M et al.
Gene, 2026
Atrophin-1 antisense oligonucleotide provides robust protection from pathology in a fully humanized DRPLA model.
Smith VL et al.
Molecular Therapy. Nucleic Acids, 2026
Advanced age and lipopolysaccharide influence behavioral and neurodegenerative features in LRRK2 G2019S knock-in mice.
Dinesh A et al.
Behavioural Brain Research, 2026
Roles in physiology and disease of the inositol phosphatase synaptojanin 1.
De Camilli P
Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids, 2026
Unraveling Parkinson's disease: The mystery of mitochondria and the role of aging.
Liu T et al.
Genes & Diseases, 2026
Role of lysosomal morphology in aging and age-related diseases.
Liu H et al.
Ageing Research Reviews, 2026
Small extracellular vesicles as emerging biomarkers and therapeutic targets in neurodegenerative diseases.
Zafarjonovna AZ et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 2026
Familial young-onset Parkinson's disease associated with SNCA gene duplication: a case series of three sisters from Turkey.
Işeri P et al.
Neurocase, 2026
An update on the monogenic causes of Parkinson's disease: Impact on patient stratification and personalised medicine.
Asmi S et al.
Ageing Research Reviews, 2026
The Age at Onset of LRRK2 p.Gly2019Ser Parkinson's Disease Across Ancestries and Countries of Origin.
Lüth T et al.
Annals of Neurology, 2026
Gene therapy targeting synaptopathy linked with Alzheimer's and Parkinson's disease.
Panda SP et al.
Neuroscience, 2026
Convergent molecular pathways to inherited Parkinson's disease.
Pfeffer SR
Current Opinion in Cell Biology, 2026
CSF LRRK2: A biomarker for slower autonomic dysfunction progression in sporadic Parkinson's disease.
Chen S et al.
Autonomic Neuroscience : Basic & Clinical, 2026
SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids.
Statoulla E et al.
Npj Parkinson's Disease, 2026
Integrated Stress Response Signatures Drive Monocyte Dysfunction in GBA1- and LRRK2-Linked Parkinson's Disease.
Mattei D et al.
Research Square, 2026
Correction: LRRK2 G2019S mutation contributes to mitochondrial transfer dysfunction in a Drp1-STX17-dependent manner.
Ding M et al.
Translational Neurodegeneration, 2026
Membrane Dysfunction as a Central Mechanism in LRRK2-Associated Parkinson's Disease: Comparative Analysis of G2019S and I1371V Variants.
Singh K et al.
Cells, 2026
Glucosylceramide-induced ectosomes propagate pathogenic α-synuclein in Parkinson's disease.
Jacquemyn J et al.
Nature Cell Biology, 2026
Parkinson's Disease Patient-Specific Striatum Organoids Show Hallmarks of Increased Inflammation.
Barmpa K et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2026
Unraveling the core: hub genes bridging familial and sporadic Parkinson's disease.
Singh S et al.
Journal of Neurology, 2026
Context-dependent ATP7 Interactions with Parkinson's Disease-associated Genes Modulate Copper Homeostasis Phenotypes.
Allen BM et al.
Biorxiv : the Preprint Server for Biology, 2026
Association of LRRK2 p.A419V with Parkinson's Disease in East Asians and analysis of age at onset.
Lim KS et al.
Npj Parkinson's Disease, 2026
Protective or Pathogenic? Kinase activity and the neurodevelopmental origins of G2019S LRRK2-Associated Parkinson's disease.
Gatto EM et al.
Parkinsonism & Related Disorders, 2026
Novel Roles for the Ectoenzyme CD38 in the Maintenance of Transcriptional and Metabolic Homeostasis in Astrocytes.
Basak S et al.
Glia, 2026
Altered subthalamic alpha-beta oscillations in PRKN-associated early onset Parkinson's disease in relation to off-dystonia.
Pavlovsky P et al.
Parkinsonism & Related Disorders, 2026
Multi-cohort, cross-species urinary proteomics reveals signatures of LRRK2 dysfunction in Parkinson's disease.
Vu DT et al.
Molecular Systems Biology, 2026
Discordance of Dopaminergic Dysfunction and Subcortical Atrophy by α-Synuclein Status in Sporadic and Genetic Parkinson's Disease.
Duong MT et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2026
LRRK2 controls COX assembly through regulation of redox status of mitochondrial copper chaperones.
Kim TY et al.
Redox Biology, 2026
Genetic predispositions and nutritional strategies: a review of nutrigenomics in Parkinson's disease.
Mohamed YA et al.
Neuroscience, 2026
Polygenic backgrounds influence phenotypic consequences of variants in cells, individuals, and populations.
Chapel M et al.
Cell Genomics, 2026
Progranulin is increased during prodromal pathology in LRRK2 G2019S mice.
Moon SH et al.
Biochemical and Biophysical Research Communications, 2026
Analysis of α-synuclein seed amplification assay in carriers of GBA1 and LRRK2 pathogenic variants.
Fraser KB et al.
Journal of Parkinson's Disease, 2026
LRRK2 kinase activity restricts NRF2-dependent mitochondrial protection in microglia.
Weindel CG et al.
Journal of Immunology (baltimore, Md. : 1950), 2026
Genetic testing for adult-onset neurodegenerative diseases: A clinical perspective.
Lee NC et al.
Journal of the Formosan Medical Association = Taiwan Yi Zhi, 2026
In vivo Proximity & Spatial Proteomics with CRISPR Screening Identify STXBP1 as a Protective Modifier of α-synuclein Toxicity in Dopamine Neurons.
Shonai D et al.
Biorxiv : the Preprint Server for Biology, 2026
NRF2 AT THE CROSSROADS OF PARKINSON'S DISEASE AND AGING: MECHANISTIC INSIGHTS AND TRANSLATIONAL PERSPECTIVES.
Áj GY et al.
Free Radical Biology & Medicine, 2026
LRRK2 regulates ArfGAP1 membrane localization, activity and neuronal toxicity via phosphorylation within its lipid-sensing ALPS2 motif.
Shariful Islam M et al.
Biorxiv : the Preprint Server for Biology, 2026
Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice.
Beilina A et al.
Biorxiv : the Preprint Server for Biology, 2026
Metabolomic breath landscape analysis unravels lipid biomarker candidates in patients with genetic and idiopathic Parkinson's disease.
Malik M et al.
Npj Parkinson's Disease, 2026
Oxidative Stress and Lysosomal Dysfunction in Neurodegenerative Diseases: Underlying Mechanisms and Nanotherapeutic Targeting Strategies.
Hu Y et al.
Antioxidants (basel, Switzerland), 2026
Carriers of LRRK2 pathogenic variants show a milder, anatomically distinct brain signature of Parkinson's disease.
Kopal J et al.
Communications Medicine, 2026
Genetic insights from Parkinson disease in African and African admixed populations.
Rizig M et al.
Nature Reviews. Neurology, 2026
Structure, Function, Pathomechanisms and Targeting of TDP-43 in Neurodegeneration.
Zhang X et al.
Brain Research, 2026