Associated Papers
Association of LRRK2 p.A419V with Parkinson's Disease in East Asians and analysis of age at onset.
Lim KS et al.
Npj Parkinson's Disease, 2026
Different Contribution of Missense and Loss-of-Function Variants to the Genetic Structure of Familial and Sporadic Meniere Disease.
Parra-Perez AM et al.
Medcomm, 2025
LRRK2 rare-variant per-domain genetic burden in Parkinson's Disease: association confined to the kinase domain.
Parlar SC et al.
Npj Parkinson's Disease, 2025
Relevance of genetic testing in the gene-targeted trial era: the Rostock Parkinson's disease study.
Westenberger A et al.
Brain : a Journal of Neurology, 2024
A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2.
Dederer V et al.
The Journal of Biological Chemistry, 2024
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding.
Kalogeropulou AF et al.
The Biochemical Journal, 2022
Crystal structure of the WD40 domain dimer of LRRK2.
Zhang P et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019
Case-control analysis of LRRK2 protective variants in Essential Tremor.
Ng ASL et al.
Scientific Reports, 2018
Leucine-Rich Repeat Kinase (LRRK2) Genetics and Parkinson's Disease.
Monfrini E et al.
Advances in Neurobiology, 2017
Benign tremulous Parkinsonism: a unique entity or another facet of Parkinson's disease?
Deeb W et al.
Translational Neurodegeneration, 2016
Parkinson's disease, genetic variability and the Faroe Islands.
Petersen MS et al.
Parkinsonism & Related Disorders, 2015
Structural and functional in silico analysis of LRRK2 missense substitutions.
Cardona F et al.
Molecular Biology Reports, 2014
Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe.
Rubio JP et al.
Human Mutation, 2012
Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.
Ross OA et al.
The Lancet. Neurology, 2011
Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update.
Nuytemans K et al.
Human Mutation, 2010
LRRK2 gene variation and its contribution to Parkinson disease.
Paisán-Ruiz C
Human Mutation, 2009
Novel GFAP mutation in patient with adult-onset Alexander disease presenting with spastic ataxia.
Kaneko H et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2009
Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease.
Biskup S et al.
Biochimica Et Biophysica Acta, 2009
Tremor dominant parkinsonism: Clinical description and LRRK2 mutation screening.
Clarimón J et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2008
Deep brain stimulation for levodopa-refractory benign tremulous parkinsonism.
Konno T et al.
Neurologia I Neurochirurgia Polska, 0