Associated Papers
MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA.
Meng J et al.
The Journal of Biological Chemistry, 2010
Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition.
Gruber A et al.
The Journal of Biological Chemistry, 2004
Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction.
Visintin A et al.
The Journal of Biological Chemistry, 2003
Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.
Latz E et al.
The Journal of Biological Chemistry, 2002
Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.
Schromm AB et al.
The Journal of Experimental Medicine, 2001
Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses.
Means TK et al.
Journal of Immunology (baltimore, Md. : 1950), 2001
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