Varaico: Literature-Extracted Genetic Variants

Gene:LYN
Variant:p.L105L
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LYN

NM_002350.4:p.L105L

Associated Papers

Causes of resistance and treatment choices of second- and third-line treatment in chronic myelogenous leukemia patients.

Hochhaus A et al.

Annals of Hematology, 2015

Second-Generation Tyrosine Kinase Inhibitors (Tki) as Salvage Therapy for Resistant or Intolerant Patients to Prior TKIs.

Breccia M et al.

Mediterranean Journal of Hematology and Infectious Diseases, 2014

Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036.

Chan WW et al.

Cancer Cell, 2011

Selecting optimal second-line tyrosine kinase inhibitor therapy for chronic myeloid leukemia patients after imatinib failure: does the BCR-ABL mutation status really matter?

Branford S et al.

Blood, 2009

AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance.

O'Hare T et al.

Cancer Cell, 2009

BCR-ABL mutational studies for predicting the response of patients with chronic myeloid leukaemia to second-generation tyrosine kinase inhibitors after imatinib failure.

Kwan TK et al.

Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."