Varaico: Literature-Extracted Genetic Variants

Gene:LYN
Variant:p.Y508F
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LYN

NM_002350.4:p.Y508F

Associated Papers

The dualistic role of Lyn tyrosine kinase in immune cell signaling: implications for systemic lupus erythematosus.

L'Estrange-Stranieri E et al.

Frontiers in Immunology, 2024

Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome.

de Jesus AA et al.

Nature Communications, 2023

De Novo Gain-Of-Function Variations in LYN Associated With an Early-Onset Systemic Autoinflammatory Disorder.

Louvrier C et al.

Arthritis & Rheumatology (hoboken, N.j.), 2023

Primary Immunodeficiency Disease Mimicking Pediatric Bechet's Disease.

Shiraki M et al.

Children (basel, Switzerland), 2021

Monogenic mimics of Behçet's disease in the young.

Papadopoulou C et al.

Rheumatology (oxford, England), 2019

Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells.

Tornillo G et al.

Cell Reports, 2018

Clinical impact of a targeted next-generation sequencing gene panel for autoinflammation and vasculitis.

Omoyinmi E et al.

Plos One, 2017

Involvement of the HCK and FGR src-family kinases in FCRL4-mediated immune regulation.

Liu Y et al.

Journal of Immunology (baltimore, Md. : 1950), 2015

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."