Varaico: Literature-Extracted Genetic Variants

Gene:MAP2K1
Variant:p.L215P
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MAP2K1

NM_002755.4:p.L215P

Associated Papers

Comprehensive genetic profiling using tissue and blood in locally advanced tumors.

Fujiyoshi K et al.

Oncology Reports, 2025

Clinical Validation of Local Versus Commercial Genomic Testing in Cancer: A Comparison of Tissue and Plasma Concordance.

Faulkner LG et al.

Cancer Investigation, 2025

Evolutionary history of MEK1 illuminates the nature of deleterious mutations.

Andrianova EP et al.

Proceedings of the National Academy of Sciences of the United States of America, 2023

37579140 (PubMed )
Supplement: pnas.2304184120.sapp.pdf

Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer.

Clarke PA et al.

Oncogene, 2019

Integrative omics analyses broaden treatment targets in human cancer.

Sengupta S et al.

Genome Medicine, 2018

30053901 (PubMed )
Supplement: 13073_2018_564_MOESM2_ESM.xlsx › 3

Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.

Morris EJ et al.

Cancer Discovery, 2013

MEK1 mutations confer resistance to MEK and B-RAF inhibition.

Emery CM et al.

Proceedings of the National Academy of Sciences of the United States of America, 2009

Genome Analysis of Osteosarcoma Progression Samples Identifies FGFR1 Overexpression as a Potential Treatment Target and CHM as a Candidate Tumor Suppressor Gene.

Barøy T et al.

Plos One, 0

27685995 (PubMed )
Supplement: pone.0163859.s005.xlsx › OS106
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