Varaico: Literature-Extracted Genetic Variants

Gene:MAP2K2
Variant:p.R4R
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MAP2K2

NM_030662.4:p.R4R

Associated Papers

A prospective, multicenter, comprehensive genomic profile signature study in patients with EGFR-mutant advanced non-small cell lung cancer at the first-line treatment failure of osimertinib.

Shi Y et al.

Signal Transduction and Targeted Therapy, 2025

41326340 (PubMed )
Supplement: 41392_2025_2481_MOESM1_ESM.docx

Histological evidence of MAPK pathway activation across subtypes of adult orbital xanthogranulomatous disease irrespective of the detection of oncogenic mutations.

Detiger SE et al.

Clinical Immunology (orlando, Fla.), 2024

KRAS G12C mutations in Asia: a landscape analysis of 11,951 Chinese tumor samples.

Loong HH et al.

Translational Lung Cancer Research, 2020

A Real-World Study in Advanced Non-Small Cell Lung Cancer with KRAS Mutations.

Lei L et al.

Translational Oncology, 2020

Analysis of KRAS and BRAF genes mutation in the central nervous system metastases of non-small cell lung cancer.

Nicoś M et al.

Clinical and Experimental Medicine, 2016

C4ST-1/CHST11-controlled chondroitin sulfation interferes with oncogenic HRAS signaling in Costello syndrome.

Klüppel M et al.

European Journal of Human Genetics : Ejhg, 2012

The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation.

Tidyman WE et al.

Current Opinion in Genetics & Development, 2009

The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders.

Aoki Y et al.

Human Mutation, 2008

Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome.

Schulz AL et al.

Clinical Genetics, 2008

Further evidence of genetic heterogeneity in Costello syndrome: involvement of the KRAS gene.

Bertola DR et al.

Journal of Human Genetics, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."