Varaico: Literature-Extracted Genetic Variants

Gene:MAP3K11
Variant:p.L410P
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MAP3K11

NM_002419.4:p.L410P

Associated Papers

Genetic analysis of slipper/mixed lineage kinase reveals requirements in multiple Jun-N-terminal kinase-dependent morphogenetic events during Drosophila development.

Polaski S et al.

Genetics, 2006

A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation.

Chadee DN et al.

Cell Cycle (georgetown, Tex.), 2004

Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain.

Zhang H et al.

The Journal of Biological Chemistry, 2001

Zipper-mediated oligomerization of the mixed lineage kinase SPRK/MLK-3 is not required for its activation by the GTPase cdc 42 but Is necessary for its activation of the JNK pathway. Monomeric SPRK L410P does not catalyze the activating phosphorylation of Thr258 of murine MITOGEN-ACTIVATED protein kinase kinase 4.

Vacratsis PO et al.

The Journal of Biological Chemistry, 2000

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."