Varaico: Literature-Extracted Genetic Variants

Gene:MAP3K21
Variant:p.R470C
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MAP3K21

NM_032435.3:p.R470C

Associated Papers

Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis.

Marusiak AA et al.

Cancer Research, 2016

Mutational landscape of mucinous ovarian carcinoma and its neoplastic precursors.

Ryland GL et al.

Genome Medicine, 2015

26257827 (PubMed )
Supplement: 13073_2015_210_MOESM1_ESM.xlsx › Table_S3

Mixed lineage kinase MLK4 is activated in colorectal cancers where it synergistically cooperates with activated RAS signaling in driving tumorigenesis.

Martini M et al.

Cancer Research, 2013

Cloning and Initial Functional Characterization of Mlk4α and Mlk4β.

Kashuba VI et al.

Genomics Insights, 2011

Absence of tyrosine kinase mutations in Japanese colorectal cancer patients.

Shao RX et al.

Oncogene, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."