Varaico: Literature-Extracted Genetic Variants

Gene:MAP4K4
Variant:p.K54R
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MAP4K4

NM_001395002.1:p.K54R

Associated Papers

Discriminating activating, deactivating and resistance variants in protein kinases.

Singh G et al.

Genome Medicine, 2025

41152984 (PubMed )
Supplement: 13073_2025_1564_MOESM2_ESM.xlsx › Table_S6

Chemical screens in aging-relevant human motor neurons identify MAP4Ks as therapeutic targets for amyotrophic lateral sclerosis.

Liu ML et al.

Biorxiv : the Preprint Server for Biology, 2023

MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins.

Fuller SJ et al.

The Biochemical Journal, 2021

Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agents.

Deng M et al.

Science Advances, 2020

STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells.

Kim JW et al.

Elife, 2020

STRIPAK integrates upstream signals to initiate the Hippo kinase cascade.

Chen R et al.

Nature Cell Biology, 2019

MAP4K4 controlled integrin β1 activation and c-Met endocytosis are associated with invasive behavior of medulloblastoma cells.

Tripolitsioti D et al.

Oncotarget, 2018

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."