Associated Papers
Cancer hotspot mutations rewire ERK2 specificity by selective exclusion of docking interactions.
Torres Robles J et al.
The Journal of Biological Chemistry, 2025
Genomic Profiling of Cardiac Angiosarcoma Reveals Novel Targetable KDR Variants, Recurrent MED12 Mutations, and a High Burden of Germline POT1 Alterations.
Odintsov I et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2025
Assessing the predicted impact of single amino acid substitutions in MAPK proteins for CAGI6 challenges.
Turina P et al.
Human Genetics, 2025
GLI1 confers resistance to PARP inhibitors by activating the DNA damage repair pathway.
Ikeuchi H et al.
Oncogene, 2024
Identifying Comprehensive Genomic Alterations and Potential Neoantigens for Cervical Cancer Immunotherapy in a Cohort of Chinese Squamous Cell Carcinoma of the Cervix.
Wu M et al.
Biomedical and Environmental Sciences : Bes, 2024
The complex impact of cancer-related missense mutations on the stability and on the biophysical and biochemical properties of MAPK1 and MAPK3 somatic variants.
Petrosino M et al.
Human Genomics, 2023
Prognosis and Characterization of Microenvironment in Cervical Cancer Influenced by Fatty Acid Metabolism-Related Genes.
Zhou Y et al.
Journal of Oncology, 2023
Precision drugging of the MAPK pathway in head and neck cancer.
Ngan HL et al.
Npj Genomic Medicine, 2022
Somatic Mutations in Circulating Cell-Free DNA and Risk for Hepatocellular Carcinoma in Hispanics.
Jiao J et al.
International Journal of Molecular Sciences, 2021
MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling.
Ngan HL et al.
Life Science Alliance, 2020
Erlotinib sensitivity of MAPK1p.D321N mutation in head and neck squamous cell carcinoma.
Ngan HL et al.
Npj Genomic Medicine, 2020
High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants.
Razavi P et al.
Nature Medicine, 2019
Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy.
Zammataro L et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019
Analysis on GENIE reveals novel recurrent variants that affect molecular diagnosis of sizable number of cancer patients.
Koyama T et al.
Bmc Cancer, 2019
Molecular Dynamics Simulations and Dynamic Network Analysis Reveal the Allosteric Unbinding of Monobody to H-Ras Triggered by R135K Mutation.
Ni D et al.
International Journal of Molecular Sciences, 2017
Genomic Evolution after Chemoradiotherapy in Anal Squamous Cell Carcinoma.
Mouw KW et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2017