Varaico: Literature-Extracted Genetic Variants

Gene:MAPK1
Variant:p.E81K
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MAPK1

NM_002745.5:p.E81K

Associated Papers

Cancer hotspot mutations rewire ERK2 specificity by selective exclusion of docking interactions.

Torres Robles J et al.

The Journal of Biological Chemistry, 2025

Assessing the predicted impact of single amino acid substitutions in MAPK proteins for CAGI6 challenges.

Turina P et al.

Human Genetics, 2025

The complex impact of cancer-related missense mutations on the stability and on the biophysical and biochemical properties of MAPK1 and MAPK3 somatic variants.

Petrosino M et al.

Human Genomics, 2023

Prognosis and Characterization of Microenvironment in Cervical Cancer Influenced by Fatty Acid Metabolism-Related Genes.

Zhou Y et al.

Journal of Oncology, 2023

36936374 (PubMed )
Supplement: 6851036.f1.zip › supplementary_figure_1-23__1_.pdf

Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer.

Shi MJ et al.

Genome Medicine, 2020

32988402 (PubMed )
Supplement: 13073_2020_781_MOESM2_ESM.xlsx › 112_Potenti_APO-associ_panCa

Emerging roles of the αC-β4 loop in protein kinase structure, function, evolution, and disease.

Yeung W et al.

Iubmb Life, 2020

Use of patient derived orthotopic xenograft models for real-time therapy guidance in a pediatric sporadic malignant peripheral nerve sheath tumor.

Fernández-Rodríguez J et al.

Therapeutic Advances in Medical Oncology, 2020

Mutant Proteomics of Lung Adenocarcinomas Harboring Different EGFR Mutations.

Nishimura T et al.

Frontiers in Oncology, 2020

32983988 (PubMed )
Supplement: Data_Sheet_2.xlsx › AZ021

High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants.

Razavi P et al.

Nature Medicine, 2019

31768066 (PubMed )
Supplement: NIHMS1541314-supplement-1541314_SourceDataFig1.xlsx › Fig_1e

Mutation profiling of cancer drivers in Brazilian colorectal cancer.

Dos Santos W et al.

Scientific Reports, 2019

Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants.

Brenan L et al.

Cell Reports, 2016

A novel somatic MAPK1 mutation in primary ovarian mixed germ cell tumors.

Zou Y et al.

Oncology Reports, 2016

Septin Mutations in Human Cancers.

Angelis D et al.

Frontiers in Cell and Developmental Biology, 2016

Landscape of genomic alterations in cervical carcinomas.

Ojesina AI et al.

Nature, 2014

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."