Varaico: Literature-Extracted Genetic Variants

Gene:MAPK14
Variant:p.D176A
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MAPK14

NM_139012.3:p.D176A

Associated Papers

The lysosomal LAMTOR-Rag complex functions as a checkpoint for antiviral interferon production.

Feng Z et al.

The Embo Journal, 2026

Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy.

Aikio M et al.

Cell Reports, 2025

MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation.

Romero-Becerra R et al.

Elife, 2022

p38alpha is active in vitro and in vivo when monophosphorylated at threonine 180.

Askari N et al.

Biochemistry, 2009

Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.

Sumara G et al.

Cell, 2009

19135240 (PubMed )
Supplement: mmc1.pdf

Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription.

Askari N et al.

The Journal of Biological Chemistry, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."