Associated Papers
Loss of FBXW7 Correlates with Increased IDH1 Expression in Glioma and Enhances IDH1-Mutant Cancer Cell Sensitivity to Radiation.
Yang Z et al.
Cancer Research, 2022
TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.
Zhu G et al.
Nature Cell Biology, 2021
Monoubiquitination of p120-catenin is essential for TGFβ-induced epithelial-mesenchymal transition and tumor metastasis.
Wu Q et al.
Science Advances, 2020
Ancestral reconstruction reveals mechanisms of ERK regulatory evolution.
Sang D et al.
Elife, 2019
Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling.
Lun XK et al.
Molecular Cell, 2019
Tumor-suppressor NFκB2 p100 interacts with ERK2 and stabilizes PTEN mRNA via inhibition of miR-494.
Wang Y et al.
Oncogene, 2016
ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors.
Goetz EM et al.
Cancer Research, 2014
The N-terminal region of p27 inhibits HIF-1α protein translation in ribosomal protein S6-dependent manner by regulating PHLPP-Ras-ERK-p90RSK axis.
Zhang D et al.
Cell Death & Disease, 2014
Small G proteins Rac1 and Ras regulate serine/threonine protein phosphatase 5 (PP5)·extracellular signal-regulated kinase (ERK) complexes involved in the feedback regulation of Raf1.
Mazalouskas MD et al.
The Journal of Biological Chemistry, 2014
INI1/hSNF5-interaction defective HIV-1 IN mutants exhibit impaired particle morphology, reverse transcription and integration in vivo.
Mathew S et al.
Retrovirology, 2013
The ERK1/2-hepatocyte nuclear factor 4alpha axis regulates human ABCC6 gene expression in hepatocytes.
de Boussac H et al.
The Journal of Biological Chemistry, 2010
Genetic and pharmacologic dissection of Ras effector utilization in oncogenesis.
Campbell PM et al.
Methods in Enzymology, 2006
Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2.
Lents NH et al.
The Journal of Biological Chemistry, 2002
PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway.
Coles LC et al.
Oncogene, 2002
Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2.
Butch ER et al.
The Journal of Biological Chemistry, 1996
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