Varaico: Literature-Extracted Genetic Variants

Gene:MAPK3
Variant:p.A4A
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MAPK3

NM_002746.3:p.A4A

Associated Papers

A prospective, multicenter, comprehensive genomic profile signature study in patients with EGFR-mutant advanced non-small cell lung cancer at the first-line treatment failure of osimertinib.

Shi Y et al.

Signal Transduction and Targeted Therapy, 2025

41326340 (PubMed )
Supplement: 41392_2025_2481_MOESM1_ESM.docx

KRAS Mutation Subtypes and Their Association with Other Driver Mutations in Oncogenic Pathways.

Mondal K et al.

Cells, 2024

Structural modifications and kinetic effects of KRAS interactions with HRAS and NRAS: an in silico comparative analysis of KRAS mutants.

Silverman I et al.

Frontiers in Molecular Biosciences, 2024

Liquid biopsy detects genomic drivers in NSCLC without EGFR mutations by single-plex testing: WJOG13620L.

Uemura T et al.

Cancer Medicine, 2023

RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status.

Dorard C et al.

Oncogene, 2023

37020037 (PubMed )
Supplement: 41388_2023_2683_MOESM1_ESM.pdf

Mutational landscape of K-Ras substitutions at 12th position-a systematic molecular dynamics approach.

S UK et al.

Journal of Biomolecular Structure & Dynamics, 2022

KRAS mutations in implant-associated peripheral giant cell granuloma.

Martins-Chaves RR et al.

Oral Diseases, 2020

An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer.

Wang H et al.

Ebiomedicine, 2019

Binimetinib, a novel MEK1/2 inhibitor, exerts anti-leukemic effects under inactive status of PI3Kinase/Akt pathway.

Sakakibara K et al.

International Journal of Hematology, 2019

G12V and G12C mutations in the gene KRAS are associated with a poorer prognosis in primary colorectal cancer.

Hayama T et al.

International Journal of Colorectal Disease, 2019

Frequencies and prognostic role of KRAS and BRAF mutations in patients with localized pancreatic and ampullary adenocarcinomas.

Schultz NA et al.

Pancreas, 2012

The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders.

Aoki Y et al.

Human Mutation, 2008

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."