Varaico: Literature-Extracted Genetic Variants

Gene:MAPK6
Variant:p.L290V
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MAPK6

NM_002748.4:p.L290V

Associated Papers

Discriminating activating, deactivating and resistance variants in protein kinases.

Singh G et al.

Genome Medicine, 2025

41152984 (PubMed )
Supplement: 13073_2025_1564_MOESM2_ESM.xlsx › Table_S6

FBXW7-mediated ERK3 degradation regulates the proliferation of lung cancer cells.

An HJ et al.

Experimental & Molecular Medicine, 2022

Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors.

Grädler U et al.

Bioorganic & Medicinal Chemistry Letters, 2020

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.

Schrader A et al.

Nature Communications, 2018

29449575 (PubMed )
Supplement: 41467_2017_2688_MOESM20_ESM.xlsx › d__Freq_TP093

L290P/V mutations increase ERK3's cytoplasmic localization and migration/invasion-promoting capability in cancer cells.

Alsaran H et al.

Scientific Reports, 2017

XomAnnotate: Analysis of Heterogeneous and Complex Exome- A Step towards Translational Medicine.

Talukder AK et al.

Plos One, 2015

25905921 (PubMed )
Supplement: pone.0123569.s008.xls › BC7_ERR166315

Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4.

Marks JL et al.

Plos One, 2007

17487277 (PubMed )
Supplement: pone.0000426.s004.doc
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