Varaico: Literature-Extracted Genetic Variants

Gene:MAPK8
Variant:p.A53T
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MAPK8

NM_001323329.2:p.A53T

Associated Papers

Gene therapy targeting synaptopathy linked with Alzheimer's and Parkinson's disease.

Panda SP et al.

Neuroscience, 2026

Hemoglobin as a pseudoperoxidase and drug target for oxidative stress-related diseases.

Won W et al.

Signal Transduction and Targeted Therapy, 2025

40846833 (PubMed )
Supplement: 41392_2025_2366_MOESM1_ESM.docx

Role of lysosomes in physiological activities, diseases, and therapy.

Zhang Z et al.

Journal of Hematology & Oncology, 2021

Current Evidence for a Bidirectional Loop Between the Lysosome and Alpha-Synuclein Proteoforms.

Wildburger NC et al.

Frontiers in Cell and Developmental Biology, 2020

Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies.

Xilouri M et al.

Movement Disorders : Official Journal of the Movement Disorder Society, 2016

Alpha-Synuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant.

Hoenen C et al.

Plos One, 2016

Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function.

Oaks AW et al.

Plos One, 2013

Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration.

Wales P et al.

Journal of Parkinson's Disease, 2013

On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies.

Daniëls V et al.

Neuro-signals, 2011

Models for LRRK2-Linked Parkinsonism.

Li T et al.

Parkinson's Disease, 2011

Autosomal dominant Parkinson's disease and the route to new therapies.

Morris HR

Expert Review of Neurotherapeutics, 2007

Fe(II)-induced DNA damage in alpha-synuclein-transfected human dopaminergic BE(2)-M17 neuroblastoma cells: detection by the Comet assay.

Martin FL et al.

Journal of Neurochemistry, 2003

Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease.

Dev KK et al.

Neuropharmacology, 2003

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."