Associated Papers
Cytokine-induced reprogramming of human macrophages toward Alzheimer's disease-relevant molecular and cellular phenotypes in vitro.
Podleśny-Drabiniok A et al.
Cell Reports, 2025
Population-Specific Differences in Pathogenic Variants of Genes Associated with Monogenic Parkinson's Disease.
Flores-Ocampo V et al.
Genes, 2025
FTLD-MAPT mutations and short 5'UTR Tau mRNAs increase Tau translation.
da Costa PJ et al.
Nar Molecular Medicine, 2024
Fully Human Bifunctional Intrabodies Achieve Graded Reduction of Intracellular Tau and Rescue Survival of MAPT Mutation iPSC-derived Neurons.
D'Brant L et al.
Biorxiv : the Preprint Server for Biology, 2024
Novel Insights into the Genetic Basis of Progressive Supranuclear Palsy in Asian-Indian Population.
Dey S et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2024
Plasma Neurofilaments: Potential Biomarkers of SPG11-Related Hereditary Spastic Paraplegia.
Krumm L et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2024
Overlaps and divergences between tauopathies and synucleinopathies: a duet of neurodegeneration.
Li W et al.
Translational Neurodegeneration, 2024
A novel MAPT variant (E342K) as a cause of familial progressive supranuclear palsy.
Li H et al.
Frontiers in Neurology, 2024
Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration?
Brackhan M et al.
Antioxidants (basel, Switzerland), 2023
Tau, microtubule dynamics, and axonal transport: New paradigms for neurodegenerative disease.
Cario A et al.
Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology, 2023
Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons.
Christensen KR et al.
Molecular Neurobiology, 2023
Differential Regulation of Tau Exon 2 and 10 Isoforms in Huntington's Disease Brain.
Petry S et al.
Neuroscience, 2023
FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation.
Chen D et al.
Nature Communications, 2023
Genetics of Multiple System Atrophy and Progressive Supranuclear Palsy: A Systemized Review of the Literature.
Bougea A
International Journal of Molecular Sciences, 2023
The N-terminal disease-associated R5L Tau mutation increases microtubule shrinkage rate due to disruption of microtubule-bound Tau patches.
Cario A et al.
The Journal of Biological Chemistry, 2022
Genetic and Epigenetic Constructs of Progressive Supranuclear Palsy.
Debnath M et al.
Annals of Neurosciences, 2022
The pathogenic R5L mutation disrupts formation of Tau complexes on the microtubule by altering local N-terminal structure.
Cario A et al.
Proceedings of the National Academy of Sciences of the United States of America, 2022
Tau mRNA Metabolism in Neurodegenerative Diseases: A Tangle Journey.
da Costa PJ et al.
Biomedicines, 2022
Genotype-Phenotype Correlation in Progressive Supranuclear Palsy Syndromes: Clinical and Radiological Similarities and Specificities.
Ruiz-Barrio I et al.
Frontiers in Neurology, 2022
Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport through a Protein Phosphatase 1γ-Dependent Mechanism.
Combs B et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2021
Genetics of Progressive Supranuclear Palsy: A Review.
Wen Y et al.
Journal of Parkinson's Disease, 2021
Tau Protein and Frontotemporal Dementias.
Goedert M et al.
Advances in Experimental Medicine and Biology, 2021
The Frequency of Genetic Mutations Associated With Behavioral Variant Frontotemporal Dementia in Chinese Han Patients.
Liu L et al.
Frontiers in Aging Neuroscience, 2021
The Biological Significance of Multi-copy Regions and Their Impact on Variant Discovery.
Sun J et al.
Genomics, Proteomics & Bioinformatics, 2020
Alzheimer's disease: phenotypic approaches using disease models and the targeting of tau protein.
Lauretti E et al.
Expert Opinion on Therapeutic Targets, 2020
Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study.
Moore KM et al.
The Lancet. Neurology, 2020
Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population.
Zhou X et al.
Alzheimer's & Dementia (amsterdam, Netherlands), 2020
Much More Than a Cytoskeletal Protein: Physiological and Pathological Functions of the Non-microtubule Binding Region of Tau.
Brandt R et al.
Frontiers in Neurology, 2020
Impaired tau-microtubule interactions are prevalent among pathogenic tau variants arising from missense mutations.
Xia Y et al.
The Journal of Biological Chemistry, 2019
MAPT mutations, tauopathy, and mechanisms of neurodegeneration.
Strang KH et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 2019
Genetic analysis of neurodegenerative diseases in a pathology cohort.
Blauwendraat C et al.
Neurobiology of Aging, 2019
FTDP-17 Mutations Alter the Aggregation and Microtubule Stabilization Propensity of Tau in an Isoform-Specific Fashion.
Mutreja Y et al.
Biochemistry, 2019
Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects.
Barbier P et al.
Frontiers in Aging Neuroscience, 2019
Annexins A2 and A6 interact with the extreme N terminus of tau and thereby contribute to tau's axonal localization.
Gauthier-Kemper A et al.
The Journal of Biological Chemistry, 2018
Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies.
Forrest SL et al.
Brain : a Journal of Neurology, 2018
A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo.
Bardai FH et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2018
Tau Filaments and the Development of Positron Emission Tomography Tracers.
Goedert M et al.
Frontiers in Neurology, 2018
Intrafamilial phenotypic heterogeneity in a Taiwanese family with a MAPT p.R5H mutation: a case report and literature review.
Lin HC et al.
Bmc Neurology, 2017
Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?
De Vos KJ et al.
Neurobiology of Disease, 2017
Cryo-EM structures of tau filaments from Alzheimer's disease.
Fitzpatrick AWP et al.
Nature, 2017
Genetics of Frontotemporal Dementia.
Olszewska DA et al.
Current Neurology and Neuroscience Reports, 2016
Quantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants.
Kimura T et al.
Scientific Reports, 2016
Tau mis-splicing in the pathogenesis of neurodegenerative disorders.
Park SA et al.
Bmb Reports, 2016
Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD.
Sydow A et al.
Acta Neuropathologica Communications, 2016
Mutation Frequency of the Major Frontotemporal Dementia Genes, MAPT, GRN and C9ORF72 in a Turkish Cohort of Dementia Patients.
Guven G et al.
Plos One, 2016