Associated Papers
Gene therapy targeting synaptopathy linked with Alzheimer's and Parkinson's disease.
Panda SP et al.
Neuroscience, 2026
Tau protein: Physiological functions and multifaceted roles in neurodegenerative and psychiatric disorders.
Tang F et al.
Genomic Psychiatry : Advancing Science From Genes to Society, 2025
Pathological and Molecular Insights into the Early Stage of Multiple System Atrophy.
Tanaka MT et al.
Cells, 2025
Alpha-Synuclein Neurobiology in Parkinson's Disease: A Comprehensive Review of Its Role, Mechanisms, and Therapeutic Perspectives.
Pitton Rissardo J et al.
Brain Sciences, 2025
The Christchurch point mutation in mouse APOE reduces Aβ-induced tau and α-synuclein pathologies.
Soto-Faguás CM et al.
Biorxiv : the Preprint Server for Biology, 2025
The Aggregation Continuum of α-Synuclein and Its Relevance to Brain Aging.
Rana A et al.
Acs Chemical Neuroscience, 2025
Cholesterol-mediated Lysosomal Dysfunction in APOE4 Astrocytes Promotes α-Synuclein Pathology in Human Brain Tissue.
Mesentier-Louro LA et al.
Biorxiv : the Preprint Server for Biology, 2025
Insights Into Retinal Pathologies in Neurological Disorders: A Focus on Parkinson's Disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease.
Akyuz E et al.
Journal of Neuroscience Research, 2025
Mechanism and Clinical Application Prospects of Mitochondrial DNA Single Nucleotide Polymorphism in Neurodegenerative Diseases.
Xu M et al.
Neurochemical Research, 2024
TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model.
Kim J et al.
Nature Neuroscience, 2024
Targeting Protein Misfolding and Aggregation as a Therapeutic Perspective in Neurodegenerative Disorders.
Sidoryk-Węgrzynowicz M et al.
International Journal of Molecular Sciences, 2024
G272V and P301L Mutations Induce Isoform Specific Tau Mislocalization to Dendritic Spines and Synaptic Dysfunctions in Cellular Models of 3R and 4R Tau Frontotemporal Dementia.
Yu K et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2024
Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice.
Benzow K et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2024
Neuronal identity defines α-synuclein and tau toxicity.
Praschberger R et al.
Neuron, 2023
Interaction Between the Glymphatic System and α-Synuclein in Parkinson's Disease.
Zhang Y et al.
Molecular Neurobiology, 2023
Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models.
Chin RM et al.
Biorxiv : the Preprint Server for Biology, 2023
Unique seeding profiles and prion-like propagation of synucleinopathies are highly dependent on the host in human α-synuclein transgenic mice.
Lloyd GM et al.
Acta Neuropathologica, 2022
Wild-Type α-Synuclein and Variants Occur in Different Disordered Dimers and Pre-Fibrillar Conformations in Early Stage of Aggregation.
Guzzo A et al.
Frontiers in Molecular Biosciences, 2022
Role of lysosomes in physiological activities, diseases, and therapy.
Zhang Z et al.
Journal of Hematology & Oncology, 2021
In vivo aggregation of presynaptic alpha-synuclein is not influenced by its phosphorylation at serine-129.
Weston LJ et al.
Neurobiology of Disease, 2021
Single-Cell Transcriptomics of Parkinson's Disease Human In Vitro Models Reveals Dopamine Neuron-Specific Stress Responses.
Fernandes HJR et al.
Cell Reports, 2020
New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy.
Guerrero-Ferreira R et al.
Current Opinion in Neurobiology, 2020
Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy.
Singh B et al.
Acta Neuropathologica, 2019
Tau interacts with SHP2 in neuronal systems and in Alzheimer's disease brains.
Kim Y et al.
Journal of Cell Science, 2019
Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity.
Farfel-Becker T et al.
Cell Reports, 2019
Sequence- and seed-structure-dependent polymorphic fibrils of alpha-synuclein.
Tanaka G et al.
Biochimica Et Biophysica Acta. Molecular Basis of Disease, 2019
O-GlcNAc Modification Protects against Protein Misfolding and Aggregation in Neurodegenerative Disease.
Ryan P et al.
Acs Chemical Neuroscience, 2019
Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy.
Li Y et al.
Cell Research, 2018
Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention.
Briston T et al.
Biochemical Society Transactions, 2018
Annexins A2 and A6 interact with the extreme N terminus of tau and thereby contribute to tau's axonal localization.
Gauthier-Kemper A et al.
The Journal of Biological Chemistry, 2018
Autonomic dysfunction in genetic forms of synucleinopathies.
Chelban V et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2018
Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.
Woerman AL et al.
Proceedings of the National Academy of Sciences of the United States of America, 2018
Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease.
Zeng XS et al.
Frontiers in Aging Neuroscience, 2018
Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature.
Schneider SA et al.
Movement Disorders : Official Journal of the Movement Disorder Society, 2017
Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture.
Miyamoto T et al.
Molecular Neurodegeneration, 2017
Alpha-synuclein at the intracellular and the extracellular side: functional and dysfunctional implications.
Ottolini D et al.
Biological Chemistry, 2017
The unfolded protein response: mechanisms and therapy of neurodegeneration.
Smith HL et al.
Brain : a Journal of Neurology, 2016
Glia and alpha-synuclein in neurodegeneration: A complex interaction.
Brück D et al.
Neurobiology of Disease, 2016
Transient β-hairpin formation in α-synuclein monomer revealed by coarse-grained molecular dynamics simulation.
Yu H et al.
The Journal of Chemical Physics, 2015
NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease.
Corsetti V et al.
Human Molecular Genetics, 2015
Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.
Vossel KA et al.
The Journal of Cell Biology, 2015
Link between the SNCA gene and parkinsonism.
Xu W et al.
Neurobiology of Aging, 2015
Genomic editing tools to model human diseases with isogenic pluripotent stem cells.
Kim HS et al.
Stem Cells and Development, 2014
Genetic variants and animal models in SNCA and Parkinson disease.
Deng H et al.
Ageing Research Reviews, 2014
Site-specific fluorescence dynamics of α-synuclein fibrils using time-resolved fluorescence studies: effect of familial Parkinson's disease-associated mutations.
Sahay S et al.
Biochemistry, 2014
Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function.
Oaks AW et al.
Plos One, 2013
Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration.
Wales P et al.
Journal of Parkinson's Disease, 2013