Associated Papers
Dysfunctional Chondroitin 4-O-Sulfotransferase-1 Impairs Cellular Redox State and Promotes Tau Aggregation.
Nadanaka S et al.
Cells, 2025
Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau.
Santambrogio A et al.
Febs Letters, 2025
A key region of Tau that is able to drive assembly and modulate inhibition by Hydromethylthionine.
Al-Hilaly YK et al.
Journal of Molecular Biology, 2025
Tubulin transforms Tau and α-synuclein condensates from pathological to physiological.
Lucas L et al.
Biorxiv : the Preprint Server for Biology, 2025
Stable ubiquitin conjugation for biological interrogation of ubiquitinated tau repeat domain.
Viola G et al.
Bioorganic Chemistry, 2024
The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70.
Velasco-Carneros L et al.
Nature Communications, 2023
Mical modulates Tau toxicity via cysteine oxidation in vivo.
Prifti E et al.
Acta Neuropathologica Communications, 2022
Ubiquitination of Alzheimer's-related tau protein affects liquid-liquid phase separation in a site- and cofactor-dependent manner.
Parolini F et al.
International Journal of Biological Macromolecules, 2022
Mitochondrial ROS control neuronal excitability and cell fate in frontotemporal dementia.
Esteras N et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2022
Disulfide bond formation in microtubule-associated tau protein promotes tau accumulation and toxicity in vivo.
Saito T et al.
Human Molecular Genetics, 2021
Membrane interaction and disulphide-bridge formation in the unconventional secretion of Tau.
Hellén M et al.
Bioscience Reports, 2021
Hsp40s play complementary roles in the prevention of tau amyloid formation.
Irwin R et al.
Elife, 2021
The Two Cysteines of Tau Protein Are Functionally Distinct and Contribute Differentially to Its Pathogenicity in Vivo.
Prifti E et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2021
Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils.
Savastano A et al.
Scientific Reports, 2020
Extensive Plasmid Library to Prepare Tau Protein Variants and Study Their Functional Biochemistry.
Karikari TK et al.
Acs Chemical Neuroscience, 2020
Hyperphosphorylated tau aggregation and cytotoxicity modulators screen identified prescription drugs linked to Alzheimer's disease and cognitive functions.
Liu M et al.
Scientific Reports, 2020
The C291R Tau Variant Forms Different Types of Protofibrils.
Karikari TK et al.
Frontiers in Molecular Neuroscience, 2020
The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?
Fichou Y et al.
Acta Neuropathologica Communications, 2019
Preparation of stable tau oligomers for cellular and biochemical studies.
Karikari TK et al.
Analytical Biochemistry, 2019
Distinct Conformations, Aggregation and Cellular Internalization of Different Tau Strains.
Karikari TK et al.
Frontiers in Cellular Neuroscience, 2019
Interplay of pathogenic forms of human tau with different autophagic pathways.
Caballero B et al.
Aging Cell, 2018
Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking.
Al-Hilaly YK et al.
Journal of Molecular Biology, 2017
Pathological concentration of zinc dramatically accelerates abnormal aggregation of full-length human Tau and thereby significantly increases Tau toxicity in neuronal cells.
Hu JY et al.
Biochimica Et Biophysica Acta. Molecular Basis of Disease, 2017
Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer.
Akoury E et al.
Protein Science : a Publication of the Protein Society, 2016
Behind the curtain of tauopathy: a show of multiple players orchestrating tau toxicity.
Huang Y et al.
Cellular and Molecular Life Sciences : Cmls, 2016
Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation.
Cohen TJ et al.
Plos One, 2016
A mechanistic model of tau amyloid aggregation based on direct observation of oligomers.
Shammas SL et al.
Nature Communications, 2015
Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation.
Huang Y et al.
Cell Reports, 2014
The microtubule-associated tau protein has intrinsic acetyltransferase activity.
Cohen TJ et al.
Nature Structural & Molecular Biology, 2013
β-Sheet core of tau paired helical filaments revealed by solid-state NMR.
Daebel V et al.
Journal of the American Chemical Society, 2012
Low micromolar zinc accelerates the fibrillization of human tau via bridging of Cys-291 and Cys-322.
Mo ZY et al.
The Journal of Biological Chemistry, 2009
Structural polymorphism of 441-residue tau at single residue resolution.
Mukrasch MD et al.
Plos Biology, 2009
Assembly of two distinct dimers and higher-order oligomers from full-length tau.
Sahara N et al.
The European Journal of Neuroscience, 2007
Site-specific nitration and oxidative dityrosine bridging of the tau protein by peroxynitrite: implications for Alzheimer's disease.
Reynolds MR et al.
Biochemistry, 2005
Role of cysteine-291 and cysteine-322 in the polymerization of human tau into Alzheimer-like filaments.
Bhattacharya K et al.
Biochemical and Biophysical Research Communications, 2001