Varaico: Literature-Extracted Genetic Variants

Gene:MARCHF5
Variant:p.C65S
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MARCHF5

NM_017824.5:p.C65S

Associated Papers

TRAP1 inhibits MARCH5-mediated MIC60 degradation to alleviate mitochondrial dysfunction and apoptosis of cardiomyocytes under diabetic conditions.

Zhang L et al.

Cell Death and Differentiation, 2023

MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51.

Ito N et al.

Journal of Biochemistry, 2022

MITOL promotes cell survival by degrading Parkin during mitophagy.

Shiiba I et al.

Embo Reports, 2021

Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL.

Koyano F et al.

The Journal of Biological Chemistry, 2019

MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2.

Sugiura A et al.

Molecular Cell, 2013

A mitochondrial ubiquitin ligase MITOL controls cell toxicity of polyglutamine-expanded protein.

Sugiura A et al.

Mitochondrion, 2011

Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation.

Yonashiro R et al.

Molecular Biology of the Cell, 2009

The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division.

Karbowski M et al.

The Journal of Cell Biology, 2007

A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics.

Yonashiro R et al.

The Embo Journal, 2006

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."