Associated Papers
MARK2 variants cause autism spectrum disorder via the downregulation of WNT/β-catenin signaling pathway.
Gong M et al.
American Journal of Human Genetics, 2024
The KLDpT activation loop motif is critical for MARK kinase activity.
Sonntag T et al.
Plos One, 2019
Interconversion of inactive to active conformation of MARK2: Insights from molecular modeling and molecular dynamics simulation.
Ahrari S et al.
Archives of Biochemistry and Biophysics, 2017
Microtubule affinity-regulating kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer.
Hubaux R et al.
International Journal of Cancer, 2015
Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport.
Matenia D et al.
The Journal of Biological Chemistry, 2012
Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging-based biosensor: inhibitors with therapeutic potential.
Timm T et al.
The Journal of Biological Chemistry, 2011
TRESK background K(+) channel is inhibited by PAR-1/MARK microtubule affinity-regulating kinases in Xenopus oocytes.
Braun G et al.
Plos One, 2011
Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2.
Timm T et al.
The Journal of Biological Chemistry, 2008
Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling.
Kojima Y et al.
The Journal of Biological Chemistry, 2007
Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1.
Panneerselvam S et al.
Structure (london, England : 1993), 2006
Signaling from MARK to tau: regulation, cytoskeletal crosstalk, and pathological phosphorylation.
Timm T et al.
Neuro-degenerative Diseases, 2006
MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons.
Mandelkow EM et al.
The Journal of Cell Biology, 2004
MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption.
Drewes G et al.
Cell, 1997
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