Varaico: Literature-Extracted Genetic Variants

Gene:MC1R
Variant:p.D121N
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MC1R

NM_002386.4:p.D121N

Associated Papers

Genomic insights into the demographic history and local adaptation of wild boars across Eurasia.

Wang Z et al.

Cell Genomics, 2025

40712570 (PubMed )
Supplement: mmc4.xlsx › Table_S7

Detection of MC1R Genetic Variants and Their Association with Coat Color in Asian Goats.

Kawaguchi F et al.

Animals : an Open Access Journal From Mdpi, 2025

Genome-Wide Association Study of Birth Wool Length, Birth Weight, and Head Color in Chinese Tan Sheep Through Whole-Genome Re-Sequencing.

Ma L et al.

Animals : an Open Access Journal From Mdpi, 2024

Dark Morph of the Oriental Honey-Buzzard (Pernis ptilorhynchus orientalis) is Attributable to Specific MC1R Haplotypes.

Ono H et al.

Zoological Science, 2024

Mutations in ASIP and MC1R: dominant black and recessive black alleles segregate in native Swedish sheep populations.

Rochus CM et al.

Animal Genetics, 2019

Revealing the selection history of adaptive loci using genome-wide scans for selection: an example from domestic sheep.

Rochus CM et al.

Bmc Genomics, 2018

Allelic variation of melanocortin-1 receptor locus in Saudi indigenous sheep exhibiting different color coats.

Mahmoud AH et al.

Asian-australasian Journal of Animal Sciences, 2017

Epistatic Interaction of the Melanocortin 1 Receptor and Agouti Signaling Protein Genes Modulates Wool Color in the Brazilian Creole Sheep.

Hepp D et al.

The Journal of Heredity, 2016

Domestic animals as models for biomedical research.

Andersson L

Upsala Journal of Medical Sciences, 2016

MC1R, KIT, IGF2, and NR6A1 as markers for genetic differentiation in Thai native, wild boars, and Duroc and Chinese Meishan pigs.

Klomtong P et al.

Genetics and Molecular Research : Gmr, 2015

Ancient homology underlies adaptive mimetic diversity across butterflies.

Gallant JR et al.

Nature Communications, 2014

25198507 (PubMed )
Supplement: ncomms5817-s2.xlsx › Table_S5_-_selected_genes

Family of melanocortin receptor (MCR) genes in mammals-mutations, polymorphisms and phenotypic effects.

Switonski M et al.

Journal of Applied Genetics, 2013

Mutations in MC1R gene determine black coat color phenotype in Chinese sheep.

Yang GL et al.

Thescientificworldjournal, 2013

Genetic testing for phenotype-causing variants in sheep and goats.

Lühken G

Molecular and Cellular Probes, 2012

Identification of the e allele at the Extension locus (MC1R) in Brazilian Creole sheep and its role in wool color variation.

Hepp D et al.

Genetics and Molecular Research : Gmr, 2012

Nucleotide diversity of the melanocortin 1 receptor gene (MC1R) in the gayal (Bos frontalis).

Xi D et al.

Molecular Biology Reports, 2012

Coat colours in the Massese sheep breed are associated with mutations in the agouti signalling protein (ASIP) and melanocortin 1 receptor (MC1R) genes.

Fontanesi L et al.

Animal : an International Journal of Animal Bioscience, 2011

The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling.

Benned-Jensen T et al.

Plos One, 2011

A composite six bp in-frame deletion in the melanocortin 1 receptor (MC1R) gene is associated with the Japanese brindling coat colour in rabbits (Oryctolagus cuniculus).

Fontanesi L et al.

Bmc Genetics, 2010

Missense and nonsense mutations in melanocortin 1 receptor (MC1R) gene of different goat breeds: association with red and black coat colour phenotypes but with unexpected evidences.

Fontanesi L et al.

Bmc Genetics, 2009

Pigmentation in Black-boned sheep (Ovis aries): association with polymorphism of the MC1R gene.

Deng WD et al.

Molecular Biology Reports, 2009

The loci of evolution: how predictable is genetic evolution?

Stern DL et al.

Evolution; International Journal of Organic Evolution, 2008

18616572 (PubMed )
Supplement: evo0062-2155-sd1.xls › included_only

Differences in the expression of the ASIP gene are involved in the recessive black coat colour pattern in sheep: evidence from the rare Xalda sheep breed.

Royo LJ et al.

Animal Genetics, 2008

Variations of melanocortin receptor 1 (MC1R) gene in three pig breeds.

Dun G et al.

Journal of Genetics and Genomics = Yi Chuan Xue Bao, 2007

Molecular characterization of human melanocortin-3 receptor ligand-receptor interaction.

Chen M et al.

Biochemistry, 2006

Evolution of a pigmentation gene, the melanocortin-1 receptor, in primates.

Mundy NI et al.

American Journal of Physical Anthropology, 2003

Molecular genetics and evolution of melanism in the cat family.

Eizirik E et al.

Current Biology : Cb, 2003

A frameshift mutation in MC1R and a high frequency of somatic reversions cause black spotting in pigs.

Kijas JM et al.

Genetics, 2001

Melanocortin 1 receptor variation in the domestic dog.

Newton JM et al.

Mammalian Genome : Official Journal of the International Mammalian Genome Society, 2000

Molecular and pharmacological characterization of dominant black coat color in sheep.

Våge DI et al.

Mammalian Genome : Official Journal of the International Mammalian Genome Society, 1999

Melanocortin receptor 1 (MC1R) mutations and coat color in pigs.

Kijas JM et al.

Genetics, 1998

Molecular basis for the interaction of [Nle4,D-Phe7]melanocyte stimulating hormone with the human melanocortin-1 receptor.

Yang Yk et al.

The Journal of Biological Chemistry, 1997

Characterization of 37 breed-specific single-nucleotide polymorphisms in sheep.

Pariset L et al.

The Journal of Heredity, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."