Associated Papers
MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants.
Jamaluddin A et al.
Cell Reports, 2026
Association of Mutations in the Melanocortin-2 Receptor Accessory Protein 2 Gene (MRAP2) and Obesity: A Systematic Review and Meta-Analysis.
Ji RL et al.
International Journal of Molecular Sciences, 2026
The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling.
Jamaluddin A et al.
Science Signaling, 2025
41401256 (PubMed )
Supplement: EMS211715-supplement-Supplementary_Materials.pdf
Obesity-associated MRAP2 variants impair multiple MC4R-mediated signaling pathways.
Wyatt RA et al.
Human Molecular Genetics, 2025
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