Associated Papers
Obesity due to MC4R deficiency is associated with reduced cholesterol, triglycerides and cardiovascular disease risk.
Zorn S et al.
Nature Medicine, 2025
41102563 (PubMed )
Supplement: 41591_2025_3976_MOESM2_ESM.xlsx › Table_S4
Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to α-melanocyte-stimulating hormone (α-MSH).
McDaniel FK et al.
The Journal of Biological Chemistry, 2012
Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization.
Shinyama H et al.
Endocrinology, 2003
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