Associated Papers
Obesity due to MC4R deficiency is associated with reduced cholesterol, triglycerides and cardiovascular disease risk.
Zorn S et al.
Nature Medicine, 2025
Genetic Variability of Loci Affecting Meat Quality and Production in Nero Siciliano Pig Breed.
Tumino S et al.
Animals : an Open Access Journal From Mdpi, 2025
High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery.
Howard CJ et al.
Elife, 2025
Medical semiology of patients with monogenic obesity: A systematic review.
Renard E et al.
Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, 2024
Evaluation of the MC4R gene across eMERGE network identifies many unreported obesity-associated variants.
Namjou B et al.
International Journal of Obesity (2005), 2021
Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency.
Collet TH et al.
Molecular Metabolism, 2017
How genetic errors in GPCRs affect their function: Possible therapeutic strategies.
Stoy H et al.
Genes & Diseases, 2015
A novel MC4R mutation associated with childhood-onset obesity: A case report.
Doulla M et al.
Paediatrics & Child Health, 2014
Family of melanocortin receptor (MCR) genes in mammals-mutations, polymorphisms and phenotypic effects.
Switonski M et al.
Journal of Applied Genetics, 2013
The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.
Tao YX
Endocrine Reviews, 2010
Genetics of fat tissue accumulation in pigs: a comparative approach.
Switonski M et al.
Journal of Applied Genetics, 2010
Detailed characterization of the porcine MC4R gene in relation to fatness and growth.
Fan B et al.
Animal Genetics, 2009
Pharmacological analyses of two naturally occurring porcine melanocortin-4 receptor mutations in domestic pigs.
Fan ZC et al.
Domestic Animal Endocrinology, 2008
Association of the melanocortin 4 receptor with feed intake and daily gain in F2 Mangalitsa x Piétrain pigs.
Meidtner K et al.
Animal Genetics, 2006
Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany.
Hinney A et al.
The Journal of Clinical Endocrinology and Metabolism, 2006
Investigating genetic variants in early-onset obesity through exome sequencing: A retrospective cohort study.
Liu D et al.
Obesity Research & Clinical Practice, 0