Associated Papers
Evolutionary Identification of the Requirement of the Second Intracellular Loop for the Constitutive Activity of Melanocortin-4 Receptors.
Xu B et al.
Acs Pharmacology & Translational Science, 2024
Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Zhang H et al.
Cell Research, 2021
Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-α-MSH and setmelanotide.
Heyder NA et al.
Cell Research, 2021
Functions of transmembrane domain 3 of human melanocortin-4 receptor.
Mo XL et al.
Journal of Molecular Endocrinology, 2012
Key amino acid residues in the melanocortin-4 receptor for nonpeptide THIQ specific binding and signaling.
Yang Y et al.
Regulatory Peptides, 2009
Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo.
Srinivasan S et al.
Plos One, 2007
Contribution of the conserved amino acids of the melanocortin-4 receptor in [corrected] [Nle4,D-Phe7]-alpha-melanocyte-stimulating [corrected] hormone binding and signaling.
Chen M et al.
The Journal of Biological Chemistry, 2007
Molecular interactions of nonpeptide agonists and antagonists with the melanocortin-4 receptor.
Fleck BA et al.
Biochemistry, 2005
Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function.
Govaerts C et al.
Peptides, 2005
Interactions of human melanocortin 4 receptor with nonpeptide and peptide agonists.
Pogozheva ID et al.
Biochemistry, 2005
Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors.
Chai BX et al.
Biochemistry, 2005
Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans.
Srinivasan S et al.
The Journal of Clinical Investigation, 2004
Molecular determinants of ligand binding to the human melanocortin-4 receptor.
Yang YK et al.
Biochemistry, 2000
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