Associated Papers
A conserved functional missense SNP (E100K) in sheep MC4R gene leading to functional loss and impacting the growth traits.
Yang Y et al.
Journal of Animal Science, 2026
Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Zhang H et al.
Cell Research, 2021
Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-α-MSH and setmelanotide.
Heyder NA et al.
Cell Research, 2021
The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling.
Benned-Jensen T et al.
Plos One, 2011
Key amino acid residues in the melanocortin-4 receptor for nonpeptide THIQ specific binding and signaling.
Yang Y et al.
Regulatory Peptides, 2009
Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.
Tan K et al.
Endocrinology, 2009
Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo.
Srinivasan S et al.
Plos One, 2007
Contribution of the conserved amino acids of the melanocortin-4 receptor in [corrected] [Nle4,D-Phe7]-alpha-melanocyte-stimulating [corrected] hormone binding and signaling.
Chen M et al.
The Journal of Biological Chemistry, 2007
Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function.
Govaerts C et al.
Peptides, 2005
Interactions of human melanocortin 4 receptor with nonpeptide and peptide agonists.
Pogozheva ID et al.
Biochemistry, 2005
Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors.
Chai BX et al.
Biochemistry, 2005
Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans.
Srinivasan S et al.
The Journal of Clinical Investigation, 2004
Molecular determinants of ligand binding to the human melanocortin-4 receptor.
Yang YK et al.
Biochemistry, 2000
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