Associated Papers
Interplay between protein acetylation and ubiquitination controls MCL1 protein stability.
Shimizu K et al.
Cell Reports, 2021
Deguelin suppresses non-small cell lung cancer by inhibiting EGFR signaling and promoting GSK3β/FBW7-mediated Mcl-1 destabilization.
Gao F et al.
Cell Death & Disease, 2020
Targeting FBW7 as a Strategy to Overcome Resistance to Targeted Therapy in Non-Small Cell Lung Cancer.
Ye M et al.
Cancer Research, 2017
PAK1 Is a Novel Therapeutic Target in Tyrosine Kinase Inhibitor-Resistant Lung Adenocarcinoma Activated by the PI3K/AKT Signaling Regardless of EGFR Mutation.
Wu DW et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2016
Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.
Bailey ML et al.
Genetics, 2015
Serine 162, an essential residue for the mitochondrial localization, stability and anti-apoptotic function of Mcl-1.
Thomas LW et al.
Plos One, 2012
Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancer.
Nifoussi SK et al.
Plos One, 2012
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.
Wertz IE et al.
Nature, 2011
Mcl-1 degradation during hepatocyte lipoapoptosis.
Masuoka HC et al.
The Journal of Biological Chemistry, 2009
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