Associated Papers
Physiological functions and pharmacological targeting of transient receptor potential channels.
Chubanov V et al.
Pharmacological Reviews, 2025
Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.
Zhou X et al.
Nature Structural & Molecular Biology, 2017
The mucolipin-2 (TRPML2) ion channel: a tissue-specific protein crucial to normal cell function.
Cuajungco MP et al.
Pflugers Archiv : European Journal of Physiology, 2016
Role of TRPML and two-pore channels in endolysosomal cation homeostasis.
Grimm C et al.
The Journal of Pharmacology and Experimental Therapeutics, 2012
Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules.
Grimm C et al.
The Journal of Biological Chemistry, 2012
The TRPML3 channel: from gene to function.
Noben-Trauth K
Advances in Experimental Medicine and Biology, 2011
Constitutive activity of the human TRPML2 channel induces cell degeneration.
Lev S et al.
The Journal of Biological Chemistry, 2010
The calcium channel mucolipin-3 is a novel regulator of trafficking along the endosomal pathway.
Martina JA et al.
Traffic (copenhagen, Denmark), 2009
Life and death of sensory hair cells expressing constitutively active TRPML3.
Grimm C et al.
The Journal of Biological Chemistry, 2009
TRPML3 mutations cause impaired mechano-electrical transduction and depolarization by an inward-rectifier cation current in auditory hair cells of varitint-waddler mice.
van Aken AF et al.
The Journal of Physiology, 2008
The varitint-waddler mouse phenotypes and the TRPML3 ion channel mutation: cause and consequence.
Cuajungco MP et al.
Pflugers Archiv : European Journal of Physiology, 2008
The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration.
Nagata K et al.
Proceedings of the National Academy of Sciences of the United States of America, 2008
Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype.
Kim HJ et al.
The Journal of Biological Chemistry, 2007
A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse.
Grimm C et al.
Proceedings of the National Academy of Sciences of the United States of America, 2007
Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice.
Xu H et al.
Proceedings of the National Academy of Sciences of the United States of America, 2007
TRPML3 and hearing loss in the varitint-waddler mouse.
Atiba-Davies M et al.
Biochimica Et Biophysica Acta, 2007
Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice.
Di Palma F et al.
Proceedings of the National Academy of Sciences of the United States of America, 2002