Varaico: Literature-Extracted Genetic Variants

Gene:MDC1
Variant:p.K1936M
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MDC1

NM_014641.3:p.K1936M

Associated Papers

Evolved histone tail regulates 53BP1 recruitment at damaged chromatin.

Kelliher JL et al.

Nature Communications, 2024

A dual interaction between the DNA damage response protein MDC1 and the RAG1 subunit of the V(D)J recombinase.

Coster G et al.

The Journal of Biological Chemistry, 2012

MDC1 is ubiquitylated on its tandem BRCT domain and directly binds RAP80 in a UBC13-dependent manner.

Strauss C et al.

Dna Repair, 2011

The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome.

Coster G et al.

The Journal of Biological Chemistry, 2007

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.

Stucki M et al.

Cell, 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."