Associated Papers
Microhomology-mediated end joining acts directly on replication forks to repair single-ended double strand breaks.
Li S et al.
Biorxiv : the Preprint Server for Biology, 2026
Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy.
McFaline-Figueroa JL et al.
Cell Genomics, 2024
Nuclear transport surveillance of p53 by nuclear pores in glioblastoma.
Ikliptikawati DK et al.
Cell Reports, 2023
FAM193A is a positive regulator of p53 activity.
Szwarc MM et al.
Cell Reports, 2023
Small-Molecule NSC59984 Induces Mutant p53 Degradation through a ROS-ERK2-MDM2 Axis in Cancer Cells.
Zhang S et al.
Molecular Cancer Research : Mcr, 2022
Histone demethylase KDM4C controls tumorigenesis of glioblastoma by epigenetically regulating p53 and c-Myc.
Lee DH et al.
Cell Death & Disease, 2021
MDM2/X Inhibitors as Radiosensitizers for Glioblastoma Targeted Therapy.
Miles X et al.
Frontiers in Oncology, 2021
Targeted Brain Tumor Therapy by Inhibiting the MDM2 Oncogene: In Vitro and In Vivo Antitumor Activity and Mechanism of Action.
Punganuru SR et al.
Cells, 2020
Identifying the determinants of response to MDM2 inhibition.
Saiki AY et al.
Oncotarget, 2015
Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor.
Costa B et al.
Plos One, 2013
Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme.
Villalonga-Planells R et al.
Plos One, 2011
Polymorphisms in promoter sequences of the p15 ( INK4B ) and PTEN genes of normal Japanese individuals.
Ohsaka Y et al.
Biochemical Genetics, 2010
Polymorphisms in promoter sequences of MDM2, p53, and p16 genes in normal Japanese individuals.
Ohsaka Y et al.
Genetics and Molecular Biology, 2010
MDM2 SNP309 promoter polymorphism, an independent prognostic factor in chronic lymphocytic leukemia.
Willander K et al.
European Journal of Haematology, 2010
Caffeine confers radiosensitization of PTEN-deficient malignant glioma cells by enhancing ionizing radiation-induced G1 arrest and negatively regulating Akt phosphorylation.
Sinn B et al.
Molecular Cancer Therapeutics, 2010
MDM2 and its splice variant messenger RNAs: expression in tumors and down-regulation using antisense oligonucleotides.
Bartel F et al.
Molecular Cancer Research : Mcr, 2004
Growth inhibition of glioblastoma cells by human Pur(alpha).
Darbinian N et al.
Journal of Cellular Physiology, 2001
ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation.
de Toledo SM et al.
Oncogene, 2000
Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines.
Rich JN et al.
The Journal of Biological Chemistry, 1999
Transactivation of the human p53 tumor suppressor gene by c-Myc/Max contributes to elevated mutant p53 expression in some tumors.
Roy B et al.
Molecular and Cellular Biology, 1994