Varaico: Literature-Extracted Genetic Variants

Gene:MDM2
Variant:p.Y54F
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MDM2

NM_002392.6:p.Y54F

Associated Papers

Suppression of stress granule formation is a vulnerability imposed by mutant p53.

Thoenen E et al.

Nature Communications, 2025

Recent Advances on Mutant p53: Unveiling Novel Oncogenic Roles, Degradation Pathways, and Therapeutic Interventions.

Cordani M et al.

Biomolecules, 2024

FAM193A is a positive regulator of p53 activity.

Szwarc MM et al.

Cell Reports, 2023

36897777 (PubMed )
Supplement: NIHMS1887291-supplement-Table_S1.xlsx › SuppFile1

p53 immunostaining pattern is a useful surrogate marker for TP53 gene mutations.

Sung YN et al.

Diagnostic Pathology, 2022

36471402 (PubMed )
Supplement: 13000_2022_1273_MOESM1_ESM.docx

Deep Molecular and In Silico Protein Analysis of p53 Alteration in Myelodysplastic Neoplasia and Acute Myeloid Leukemia.

Madarász K et al.

Cells, 2022

Identifying the determinants of response to MDM2 inhibition.

Saiki AY et al.

Oncotarget, 2015

25730903 (PubMed )
Supplement: oncotarget-06-7701-s002.xls › Proliferation

Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay.

Di Como CJ et al.

Oncogene, 1998

P53 mutants suppress ZBP-89 function.

Okada M et al.

Anticancer Research, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."