Associated Papers
FLT4 activation promotes acute lymphoid leukemia survival through stabilization of MDM2/MDMX and inactivation of p53.
Haferssas D et al.
Oncogenesis, 2025
MDM2 up-regulates the energy metabolism in NSCLC in a p53-independent manner.
Fefilova E et al.
Biochemical and Biophysical Research Communications, 2025
Hdm2 disrupts HdmX-mediated nuclear export of p53 by sequestering it in nucleus.
Ni Y et al.
Experimental Cell Research, 2024
USP7 reduces the level of nuclear DICER, impairing DNA damage response and promoting cancer progression.
Liu X et al.
Molecular Oncology, 2024
Cancer-associated MDM2 W329G mutant attenuates ribosomal stress-mediated p53 responses to promote cell survival and glycolysis.
Lien S et al.
American Journal of Cancer Research, 2024
The RNA binding protein RALY suppresses p53 activity and promotes lung tumorigenesis.
Hu H et al.
Cell Reports, 2023
MDM2-Mediated Ubiquitination of RXRβ Contributes to Mitochondrial Damage and Related Inflammation in Atherosclerosis.
Zeng Y et al.
International Journal of Molecular Sciences, 2022
MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity.
Chinnam M et al.
Plos Genetics, 2022
The miR-19b-3p-MAP2K3-STAT3 feedback loop regulates cell proliferation and invasion in esophageal squamous cell carcinoma.
Zhang Y et al.
Molecular Oncology, 2021
The Ras-ERK signaling pathway regulates acetylated activating transcription factor 2 via p300 in pancreatic cancer cells.
Li M et al.
Annals of Translational Medicine, 2020
Single-Chain Lanthanide Luminescence Biosensors for Cell-Based Imaging and Screening of Protein-Protein Interactions.
Chen T et al.
Iscience, 2020
MDM2's dual mRNA binding domains co-ordinate its oncogenic and tumour suppressor activities.
Gnanasundram SV et al.
Nucleic Acids Research, 2020
Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcoma.
Cissé MY et al.
Science Translational Medicine, 2020
Ribosomal protein S2 interplays with MDM2 to induce p53.
Cho J et al.
Biochemical and Biophysical Research Communications, 2020
Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function.
Wang A et al.
Frontiers in Immunology, 2020
A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance.
Wang W et al.
Genes & Diseases, 2019
Hsp90β interacts with MDM2 to suppress p53-dependent senescence during skeletal muscle regeneration.
He MY et al.
Aging Cell, 2019
MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network.
Elkholi R et al.
Molecular Cell, 2019
Inhibition of DYRK1A-EGFR axis by p53-MDM2 cascade mediates the induction of cellular senescence.
Xu X et al.
Cell Death & Disease, 2019
A Single Conserved Amino Acid Residue as a Critical Context-Specific Determinant of the Differential Ability of Mdm2 and MdmX RING Domains to Dimerize.
Kosztyu P et al.
Frontiers in Physiology, 2019
Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53.
Arena G et al.
Molecular Cell, 2018
Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7.
Zhao K et al.
Embo Reports, 2018
Activation of p53 and destabilization of androgen receptor by combinatorial inhibition of MDM2 and MDMX in prostate cancer cells.
Chopra H et al.
Oncotarget, 2018
Inactivation of the MDM2 RING domain enhances p53 transcriptional activity in mice.
Tian H et al.
The Journal of Biological Chemistry, 2017
Mdm2 selectively suppresses DNA damage arising from inhibition of topoisomerase II independent of p53.
Senturk JC et al.
Oncogene, 2017
Cancer-mutated ribosome protein L22 (RPL22/eL22) suppresses cancer cell survival by blocking p53-MDM2 circuit.
Cao B et al.
Oncotarget, 2017
Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity.
Nomura K et al.
Nature Structural & Molecular Biology, 2017
Breast cancer in patients with Li-Fraumeni syndrome - a case-series study and review of literature.
Nandikolla AG et al.
Breast Cancer (dove Medical Press), 2017
Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53.
Chao T et al.
Nature Communications, 2016
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.
Carr MI et al.
Translational Cancer Research, 2016
Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53.
Riscal R et al.
Molecular Cell, 2016
RNF12 promotes p53-dependent cell growth suppression and apoptosis by targeting MDM2 for destruction.
Gao K et al.
Cancer Letters, 2016
Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination.
Frum RA et al.
Molecular Cancer Research : Mcr, 2016
Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation.
Yu ZC et al.
Nucleic Acids Research, 2016
The p53-Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans.
Coffill CR et al.
Genes & Development, 2016
MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.
Wienken M et al.
Molecular Cell, 2016
Regulation of MDM2 Stability After DNA Damage.
Li J et al.
Journal of Cellular Physiology, 2015
Functional interplay between MDM2, p63/p73 and mutant p53.
Stindt MH et al.
Oncogene, 2015
MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition.
Kovatcheva M et al.
Oncotarget, 2015
Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase.
Xu C et al.
Oncogene, 2015
The alternative translated MDMX(p60) isoform regulates MDM2 activity.
Tournillon AS et al.
Cell Cycle (georgetown, Tex.), 2015
MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4.
Marcar L et al.
Plos One, 2015
MDM2 regulates hypoxic hypoxia-inducible factor 1α stability in an E3 ligase, proteasome, and PTEN-phosphatidylinositol 3-kinase-AKT-dependent manner.
Joshi S et al.
The Journal of Biological Chemistry, 2014
HDMX folds the nascent p53 mRNA following activation by the ATM kinase.
Malbert-Colas L et al.
Molecular Cell, 2014